Var2CSA minimal CSA binding region is located within the N-terminal region
A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region
K Singh, RK Gitti, A Diouf, H Zhou, DC Gowda… - Journal of biological …, 2010 - ASBMB
Molecular interactions between the VAR2CSA protein, expressed on the surface of
Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are …
Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are …
Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A
K Singh, AG Gittis, P Nguyen, DC Gowda… - Nature structural & …, 2008 - nature.com
Plasmodium falciparum–infected erythrocytes bind to chondroitin sulfate A (CSA) in the
placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane …
placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane …
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …
Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies
P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …
High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high …
YL Tutterrow, M Avril, K Singh, CA Long… - Infection and …, 2012 - Am Soc Microbiol
Placental malaria, caused by sequestration of Plasmodium falciparum-infected erythrocytes
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria
JYA Doritchamou, R Herrera, JA Aebig… - The Journal of …, 2016 - academic.oup.com
Background. Placental malaria is caused by Plasmodium falciparum–infected erythrocytes
(IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory …
(IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory …
Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype
NK Viebig, E Levin, S Dechavanne, SJ Rogerson… - PloS one, 2007 - journals.plos.org
Infection with Plasmodium falciparum during pregnancy is one of the major causes of
malaria related morbidity and mortality in newborn and mothers. The complications of …
malaria related morbidity and mortality in newborn and mothers. The complications of …
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
TM Clausen, S Christoffersen, M Dahlbäck… - Journal of Biological …, 2012 - ASBMB
Malaria is a major global health problem. Pregnant women are susceptible to infection
regardless of previously acquired immunity. Placental malaria is caused by parasites …
regardless of previously acquired immunity. Placental malaria is caused by parasites …