[HTML][HTML] Inhibition of bladder cancer growth with homoharringtonine by inactivating integrin α5/β1-FAK/Src axis: A novel strategy for drug application

Q Wu, P Chen, J Li, Z Lin, Q Zhang, HF Kwok - Pharmacological research, 2023 - Elsevier
The application of immune checkpoint inhibitors and FGFR protein tyrosine kinase inhibitors
have made a tremendous breakthrough in bladder cancer therapy. However, inadequate …

Uncovering the action mechanism of homoharringtonine against colorectal cancer by using network pharmacology and experimental evaluation

M Qu, J Li, L Yuan - Bioengineered, 2021 - Taylor & Francis
Homoharringtonine (HHT), an Food and Drug Administration (FDA)-approved anti-leukemia
drug, exerts anti-tumor activity in several solid tumors, including colorectal cancer (CRC) …

[HTML][HTML] Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway

L Wang, D Wang, L Wu, J Cao, J Tian… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Homoharringtonine (HHT), a natural alkaloid derived from the cephalotaxus, exhibited its
anti-cancer effects in hematological malignancies clinically. However, its pesticide effects …

[HTML][HTML] Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells

W Cao, Y Liu, R Zhang, B Zhang, T Wang, X Zhu… - Scientific reports, 2015 - nature.com
Tyrosine kinase inhibitors (TKIs) are mostly used in non-small cell lung cancer (NSCLC)
treatment. Unfortunately, treatment with Gefitinib for a period of time will result in drug …

[HTML][HTML] Isorhamnetin inhibits human gallbladder cancer cell proliferation and metastasis via PI3K/AKT signaling pathway inactivation

T Zhai, X Zhang, Z Hei, L Jin, C Han, AT Ko… - Frontiers in …, 2021 - frontiersin.org
Gallbladder cancer (GBC) is the most common biliary tract tumor with a poor prognosis.
Isorhamnetin is a flavonoid compound extracted from Hippophae rhamnoides L. and has …

Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells

Y Xiu-jin, L Mao-fang - Journal of Zhejiang University-SCIENCE A, 2004 - Springer
Homoharringtonine (HHT) has currently been used successfully in the treatment of acute
and chronic myeloid leukemias and has been shown to induce apoptosis of different types of …

Homoharringtonine inhibits melanoma cells proliferation in vitro and vivo by inducing DNA damage, apoptosis, and G2/M cell cycle arrest

J Tang, G Li, T Zhang, Y Du, S Huang, J Ran… - Archives of Biochemistry …, 2021 - Elsevier
Homoharringtonine (HHT), an approved anti-leukemic alkaloid, has been reported
effectively in many types of tumor cells. However, its effect on melanoma cells has not been …

[HTML][HTML] Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo

T Yang, R Shi, L Chang, K Tang, K Chen, G Yu… - Journal of Experimental …, 2015 - Springer
Background Huachansu (HCS), a class of toxic steroids extracted from toad venom, which
has been shown to be a valuable anticancer drug in many kinds of cancers. However, the …

Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

G Jiang, AD Wu, C Huang, J Gu, L Zhang… - Cancer Prevention …, 2016 - AACR
Although our most recent studies have identified Isorhapontigenin (ISO), a novel derivative
of stilbene that isolated from a Chinese herb Gnetum cleistostachyum, for its inhibition of …

[HTML][HTML] Tanshinone IIA inhibits epithelial-mesenchymal transition in bladder cancer cells via modulation of STAT3-CCL2 signaling

SY Huang, SF Chang, KF Liao, SC Chiu - International Journal of …, 2017 - mdpi.com
Tanshinone IIA (Tan-IIA) is an extract from the widely used traditional Chinese medicine
(TCM) Danshen (Salvia miltiorrhiza), and has been found to attenuate the proliferation of …