Technological advances allowing high throughput analyses across numerous cancer
tissues have allowed much progress in understanding complex cellular signaling. In the …

Background: The PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays
a central role in cell growth, proliferation and survival not only under physiological …

An accumulating understanding of the complex pathogenesis of acute myeloid leukemia
(AML) continues to lead to promising therapeutic approaches. Among the key aberrant …

Acute myeloid leukemia (AML) primary cells express high levels of phosphorylated Akt, a
master regulator of cellular functions regarded as a promising drug target. By means of …

Background Dysregulation of the PI3Kinase/AKT pathway is involved in the pathogenesis of
many human malignancies. In acute leukemia, the AKT pathway is frequently activated …

Purpose Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy
resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …

Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …

Optimal function of multiple intracellular signaling pathways is essential for normal
regulation of cellular transcription, translation, growth, proliferation, and survival …

The phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B, PKB)/mammalian Target Of
Rapamycin (mTOR) signaling pathway plays a critical role in many cellular functions which …