Genome-Wide Association Study Identifies New Genetic Determinants of Emphysema Distribution

A El Boueiz - 2016 - search.proquest.com
Rationale: Emphysema has considerable variability in the severity and distribution of
parenchymal destruction throughout the lungs. Upper lobe predominant emphysema has …

Genome-wide association study of the genetic determinants of emphysema distribution

A Boueiz, SM Lutz, MH Cho, CP Hersh… - American journal of …, 2017 - atsjournals.org
Rationale: Emphysema has considerable variability in the severity and distribution of
parenchymal destruction throughout the lungs. Upper lobe–predominant emphysema has …

Lobar emphysema distribution is associated with 5-year radiological disease progression

A Boueiz, Y Chang, MH Cho, GR Washko, RSJ Estépar… - Chest, 2018 - Elsevier
Background Emphysema has considerable variability in its regional distribution.
Craniocaudal emphysema distribution is an important predictor of the response to lung …

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns

PJ Castaldi, MH Cho, R San José Estépar… - American journal of …, 2014 - atsjournals.org
Rationale: Emphysema is a heritable trait that occurs in smokers with and without chronic
obstructive pulmonary disease. Emphysema occurs in distinct pathologic patterns, but the …

Genome-Wide Association Study of Longitudinal Change in Quantitative Emphysema

W Kim, MH Cho, DA Lynch, EK Silverman… - B61. COPD: BASIC …, 2019 - atsjournals.org
RATIONALE: Emphysema is a key component of chronic obstructive pulmonary disease
(COPD). Genome-wide association studies (GWAS) have identified genetic factors …

Genetic determinants of emphysema distribution in the national emphysema treatment trial

DL DeMeo, CP Hersh, EA Hoffman… - American journal of …, 2007 - atsjournals.org
Rationale: Computed tomography (CT) scanning of the lung may reduce phenotypic
heterogeneity in defining subjects with chronic obstructive pulmonary disease (COPD), and …

A Genome-Wide Association Study of Emphysema in Korean Population

WJ Kim, S Sin, HM Choi, SH Bak… - … BASED STUDIES ON …, 2020 - atsjournals.org
Rationale; Emphysema is an important structural feature of chronic obstructive pulmonary
disease and known to have a heritable component. However, the detailed pathogenesis of …

Integrative Genomics of Emphysema-Associated Genes: Are We Closer to Identifying the Genetic Determinants of Lung Function?

S Sharma - American Journal of Respiratory Cell and Molecular …, 2017 - atsjournals.org
Chronic obstructive pulmonary disease (COPD), a heterogeneous disease that is
characterized by persistent respiratory symptoms and irreversible airflow obstruction, is the …

DSP variants may be associated with longitudinal change in quantitative emphysema

W Kim, MH Cho, P Sakornsakolpat, DA Lynch… - Respiratory …, 2019 - Springer
Background Emphysema, characterized by lung destruction, is a key component of Chronic
Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and …

A genome-wide association study of quantitative computed tomographic emphysema in Korean populations

S Sin, HM Choi, J Lim, J Kim, SH Bak, SS Choi… - Scientific Reports, 2021 - nature.com
Emphysema is an important feature of chronic obstructive pulmonary disease (COPD).
Genetic factors likely affect emphysema pathogenesis, but this question has predominantly …