Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Mitochondrial oxidative damage has long been known to contribute to damage in conditions
such as ischaemia–reperfusion (IR) injury in heart attack. Over the past years, we have …

Ischaemia/reperfusion (I/R) injury of the heart represents a major health burden mainly
associated with acute coronary syndromes. While timely coronary reperfusion has become …

Reactive oxygen species (ROS) generation has been implicated in many pathologies
including ischemia/reperfusion (I/R) injury. This led to multiple studies on antioxidant …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …

To clarify the relationship between reactive oxygen species (ROS) and cell death during
ischemia–reperfusion (I/R), we studied cell death mechanisms in a cellular model of I/R …

Mitochondrial reactive oxygen species production has emerged as an important
pathological mechanism in myocardial ischemia/reperfusion injury. Attempts at targeting …

Irrespective of the organ involved, restoration of blood flow to ischemic tissue is vital,
although reperfusion per se is deleterious. In the setting of vascular surgery, even subtle …