Sustained tissue hypoxia is associated with many pathophysiological conditions, including
chronic inflammation, chronic wounds, slow-healing fractures, microvascular complications …

Numerous studies have shed light on the intricate biological roles that carbon monoxide
(CO) and oxygen (O 2) play under various physiological and pathophysiological conditions …

Following injury, vascular damage results in the loss of perfusion and consequent low
oxygen tension (hypoxia) which may be exacerbated by a rapid influx of inflammatory and …

Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …

Excess vascular smooth muscle cell (VSMC) proliferation and contractility are key events in
the pathophysiology of vascular disorders induced by hypoxia. We have recently reported …

Heme oxygenase-1 (HO-1) and carbon monoxide (CO) modulate inflammation,
proliferation/cell cycle and survival in a host of pathophysiological situations by …

Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …

Hypoxia, a low O2 tension, is a fundamental feature that occurs in physiological events as
well as pathophysiological conditions, especially mentioned for its role in the mechanism of …

Background: Oxygen is vital for healing wounds. It is intricately involved in numerous
biological processes including cell proliferation, angiogenesis, and protein synthesis, which …