Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an
important autocrine trophic effect. Moreover, increased leptin levels are found in the most …

Maternal obesity is associated with increased risks of pregnancy complications. Excessive
fat mass, common to obese women, has the potential to influence production and secretion …

Leptin levels are significantly elevated in pregnant mice, rats and humans suggesting a
critical role for leptin during gestation. To address whether leptin plays a putative role in the …

Aims/hypothesis. Insulin resistance as well as marked changes in body weight and energy
metabolism are associated with pregnancy. Its impact on plasma leptin is not known and …

Leptin was initially identified as an adipocyte-derived hormone that decreases food intake
and body weight via its receptor in the hypothalamus. Subsequent animal studies revealed …

Leptin is an adipocyte-derived hormone that decreases food intake and body weight via its
receptor in the hypothalamus. In rodents, it also modulates glucose metabolism by …

Background Interrogation of the association between leptin, insulin resistance and fetal
growth may provide a biological link for the fetal programming of later metabolic health. Aims …

OBJECTIVE: Emerging evidence suggests that leptin, an adipocyte-derived hormone, may
have independent direct effects on both insulin secretion and action, in addition to its well …

Gestational diabetes mellitus (GDM) is the most frequent pathophysiological state of
pregnancy, which in many cases produces fetuses with macrosomia, requiring increased …

Available evidences suggest that leptin has inhibitory role on insulin secretion. The aim of
the work was to examine the association between plasma leptin concentrations and insulin …