The mechanisms by which immunoglobulin (Ig) G can modulate immunity have been
investigated over the past few decades. In the past three years, some studies have …

IgM and IgD expression during B cell development and differentiation is strictly and
developmentally controlled. Although studies have suggested subtle differences in B cell …

Genetic differences between humans and in vivo model systems, including mice and
nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity …

The role of endogenous natural IgM in promoting the adaptive Ab response was
investigated in newly constructed mutant mice in which B cells do not secrete IgM but still …

Allotype suppressor T-cell (Ts) populations that persist for the life of the animal arise in
(BALB/c× SJL) F (1) hybrids exposed perinatally to antibody to the paternal (Ig-1b) allotype …

Mature B cells co-express IgM and IgD B cell antigen receptors (BCR) on their surface.
While IgM BCR expression is already essential at early stages of development, the role of …

The development and establishment of the B Cell Repertoire is the net result of both genetic
and environmental forces. The primary event at the genetic level is Ig gene rearrangement …

Lymph nodes (LNs) have evolved to maximize antigen (Ag) collection and presentation as
well as lymphocyte proliferation and differentiation—processes that are spatially regulated …

Signalling through the B cell antigen receptor (BCR) is required for peripheral B lymphocyte
maturation, maintenance, activation and silencing. In mature B cells, the antigen receptor …

The driving forces that direct the emergence of the antibody repertoire in ontogeny are still
far from clear. It is generally accepted that the first steps involve learning of self-nonself …