The immunopathology of complement proteins and innate immunity in autoimmune disease

F Defendi, NM Thielens, G Clavarino… - Clinical Reviews in …, 2020 - Springer
The complement is a powerful cascade of the innate immunity and also acts as a bridge
between innate and acquired immune defence. Complement activation can occur via three …

Complement and autoimmunity

E Ballanti, C Perricone, E Greco, M Ballanti… - Immunologic …, 2013 - Springer
The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

Role of complement in innate immunity and host defense

LA Trouw, MR Daha - Immunology letters, 2011 - Elsevier
The complement system is an important part of the innate immune defense. Next to its role
as an effector mechanism of the innate immune system, complement also plays a major role …

Autoantibodies against complement components and functional consequences

MA Dragon-Durey, C Blanc, MC Marinozzi… - Molecular …, 2013 - Elsevier
The complement system represents a major component of our innate immune defense.
Although the physiological contribution of the complement system is beneficial, it can cause …

Complement in autoimmune diseases

P Vignesh, A Rawat, M Sharma, S Singh - Clinica Chimica Acta, 2017 - Elsevier
The complement system is an ancient and evolutionary conserved element of the innate
immune mechanism. It comprises of more than 20 serum proteins most of which are …

The complement system as a therapeutic target in autoimmunity

VM Holers - Clinical Immunology, 2003 - Elsevier
The complement system is a central component of innate immunity [1] and is functionally
linked to both the activation and regulatory as well as the effector arms of adaptive immunity …

[HTML][HTML] Complement as a regulator of adaptive immunity

J Killick, G Morisse, D Sieger, AL Astier - Seminars in immunopathology, 2018 - Springer
The complement system is an ancient and evolutionarily conserved effector system
comprising in mammals over 50 circulating and membrane bound proteins. Complement …

Autoantibodies to complement components

LA Trouw, A Roos, MR Daha - Molecular immunology, 2001 - Elsevier
The complement system is a major component of innate immunity. Under normal conditions
the contribution of the complement system is beneficial, but when inappropriately activated it …

[HTML][HTML] Complement as a therapeutic target in systemic autoimmune diseases

M Galindo-Izquierdo, JL Pablos Alvarez - Cells, 2021 - mdpi.com
The complement system (CS) includes more than 50 proteins and its main function is to
recognize and protect against foreign or damaged molecular components. Other …

The role of complement in inflammatory diseases from behind the scenes into the spotlight

MM Markiewski, JD Lambris - The American journal of pathology, 2007 - Elsevier
Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …