Significance of the minor cytochrome P450 3A isoforms
AK Daly - Clinical pharmacokinetics, 2006 - Springer
Abstract Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
Cytochrome P450 3A: ontogeny and drug disposition
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7
JA Williams, BJ Ring, VE Cantrell, DR Jones… - Drug Metabolism and …, 2002 - ASPET
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …
The genetic determinants of the CYP3A5 polymorphism
E Hustert, M Haberl, O Burk, R Wolbold… - Pharmacogenetics …, 2001 - journals.lww.com
CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …
Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
I Koch, R Weil, R Wolbold, J Brockmöller… - Drug Metabolism and …, 2002 - ASPET
The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A
activity has been hampered by similarities in their sequence and function. We investigated …
activity has been hampered by similarities in their sequence and function. We investigated …
Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism
A Westlind-Johnsson, S Malmebo, A Johansson… - Drug Metabolism and …, 2003 - ASPET
To study mechanisms behind the interindividual variability in CYP3A expression and the
relative contribution of the different CYP3A enzymes to the overall CYP3A activity, we have …
relative contribution of the different CYP3A enzymes to the overall CYP3A activity, we have …
Cytochrome P450 3A and their regulation
O Burk, L Wojnowski - Naunyn-Schmiedeberg's archives of pharmacology, 2004 - Springer
CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …
CYP3A5 Variant Allele Frequencies in Dutch Caucasians
RHN van Schaik, IP van der Heiden… - Clinical …, 2002 - academic.oup.com
Background: Enzymes of the cytochrome P450 3A (CYP3A) family are responsible for the
metabolism of> 50% of currently prescribed drugs. CYP3A5 is expressed in a limited …
metabolism of> 50% of currently prescribed drugs. CYP3A5 is expressed in a limited …
The human CYP3A subfamily: practical considerations
SA Wrighton, EG Schuetz, KE Thummel… - Drug metabolism …, 2000 - Taylor & Francis
The CYP3A subfamily of cytochromes P450 (CYP) in humans is composed of CYP3A4, 3A5,
and 3A7. The CYP3A forms are involved in the metabolism of an amazingly large number of …
and 3A7. The CYP3A forms are involved in the metabolism of an amazingly large number of …
CYP3A5 phenotype‐genotype correlations in a British population
BP King, JBS Leathart, E Mutch… - British journal of …, 2003 - Wiley Online Library
Aims To develop a polymerase chain reaction (PCR)‐restriction fragment length
polymorphism (RFLP)‐based assay to genotype for hepatic CYP3A5 expression and to use …
polymorphism (RFLP)‐based assay to genotype for hepatic CYP3A5 expression and to use …