Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …

Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …

Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Aging is a major risk factor for numerous human pathologies, including cardiovascular,
metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies …