Enhanced radiation sensitivity in HPV-positive head and neck cancer

RJ Kimple, MA Smith, GC Blitzer, AD Torres, JA Martin… - Cancer research, 2013 - AACR
Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …

Increased radiosensitivity of HPV-positive head and neck cancer cell lines due to cell cycle dysregulation and induction of apoptosis

A Arenz, F Ziemann, C Mayer, A Wittig… - Strahlentherapie und …, 2014 - Springer
Abstract Background and purpose Human Papillomavirus (HPV)-related head and neck
squamous cell carcinoma (HNSCC) respond favourably to radiotherapy as compared to …

Increased radiosensitivity of HPV-positive head and neck cancers: Molecular basis and therapeutic perspectives

H Mirghani, F Amen, Y Tao, E Deutsch, A Levy - Cancer treatment reviews, 2015 - Elsevier
Human papillomavirus driven head and neck squamous cell carcinoma (HNSCC),
particularly oropharyngeal squamous cell carcinoma (OPSCC), are characterized by a …

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma

C Zhou, JL Parsons - Expert reviews in molecular medicine, 2020 - cambridge.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, with reported incidences of~ 800 000 cases each year. One of the critical …

Immune response during therapy with cisplatin or radiation for human papillomavirus–related head and neck cancer

WC Spanos, P Nowicki, DW Lee… - … –head & neck …, 2009 - jamanetwork.com
Background Human papillomavirus (HPV) is the most identifiable cause of head and neck
squamous cell cancer (HNSCC). Compared with HPV-negative HNSCC, HPV-positive …

HPV-induced oropharyngeal cancer, immune response and response to therapy

HL Vu, AG Sikora, S Fu, J Kao - Cancer letters, 2010 - Elsevier
Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are
associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a …

Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non–HPV-Infected cell line and relationship to signaling through AKT

AK Gupta, JH Lee, WW Wilke, H Quon, G Smith… - International Journal of …, 2009 - Elsevier
PURPOSE: Human papilloma virus (HPV)-associated cancers of the head and neck (H&N)
are increasing in frequency and are often treated with radiation. There are conflicting data in …

HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity

T Rieckmann, S Tribius, TJ Grob, F Meyer… - Radiotherapy and …, 2013 - Elsevier
BACKGROUND AND PURPOSE: When treated by radiotherapy, patients with squamous
cell carcinomas of the head and neck (HNSCC) positive for HPV and p16INK4a possess a …

[HTML][HTML] Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation±Cisplatin due to decreased expression of E6 and E7 oncoproteins and …

F Ziemann, A Arenz, S Preising… - American journal of …, 2015 - ncbi.nlm.nih.gov
Squamous cell carcinoma of the head and neck region (HNSCC), which is related to an
infection with human papilloma virus (HPV), responds better to simultaneous radio …

[HTML][HTML] Variations in HPV function are associated with survival in squamous cell carcinoma

FO Gleber-Netto, X Rao, T Guo, Y Xi, M Gao, L Shen… - JCI insight, 2019 - ncbi.nlm.nih.gov
Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing
dramatically. Although long-term survival rates for these patients are high, they often suffer …