Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular
cargos. Numerous kinesins and myosins have evolved to cope with the various transport …

Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth
of new structural, mechanistic, and cell biological data is shedding light on how this …

A key player in the intracellular trafficking network is cytoplasmic dynein, a protein complex
that transports molecular cargo along microtubule tracks. It has been shown that vertebrate …

Since the initial discovery of cytoplasmic dynein, it has become apparent that this
microtubule-based motor is involved in several cellular functions including cell division and …

The organization and function of eukaryotic cells rely on the action of many different
molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of …

Cytoplasmic dynein is the major motor protein responsible for microtubule minus-end–
directed movements in most eukaryotic cells. It transports a variety of cargoes and has …

Cytoplasmic dynein is an AAA+ motor that drives the transport of many intracellular cargoes
towards the minus end of microtubules (MTs). Previous in vitro studies characterized …

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport
machine capable of long-distance processive movement along microtubules. However, it is …

Cytoplasmic dynein is the primary molecular motor responsible for transport of vesicles,
organelles, proteins and RNA cargoes from the periphery of the cell towards the nucleus …