The proper construction of neural circuits requires the generation of diverse cell types, their
distribution to defined regions, and their specific and appropriate wiring. A major objective in …

Highlights•Cortical interneurons originate in the embryonic subcortical
telencephalon.•Spatial and temporal control of progenitor differentiation generates …

Highlights•The GEs produce many types of GABAergic projection neurons and a majority of
GABAergic interneurons.•Spatial origin, birthdate, and mode of division influence …

The central goal of this manuscript is to survey our present knowledge of how cortical
interneuron subtypes are generated. To achieve this, we will first define what is meant by …

GABA-containing interneurons are crucial to both the development and function of the
cerebral cortex. Unlike cortical projection neurons, which have a relatively conserved set of …

GABAergic interneurons are critical components of cortical circuits. However, understanding
their function has become extremely challenging because they constitute one of the most …

Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …

In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

Previous work has demonstrated that the character of mouse cortical interneuron subtypes
can be directly related to their embryonic temporal and spatial origins. The relationship …

Precise generation of excitatory neurons and inhibitory interneurons is crucial for proper
formation and function of neural circuits in the mammalian brain. Because of the size and …