Pathophysiology of focal segmental glomerulosclerosis

K Reidy, FJ Kaskel - Pediatric Nephrology, 2007 - Springer
Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant
nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal …

Pathogenesis and therapy of focal segmental glomerulosclerosis: an update

R Gbadegesin, P Lavin, J Foreman, M Winn - Pediatric nephrology, 2011 - Springer
Focal and segmental glomerulosclerosis (FSGS) is an important cause of steroid-resistant
nephrotic syndrome in adults and children. It is responsible for 5–20% of all cases of end …

Genetic causes of focal segmental glomerulosclerosis: implications for clinical practice

IM Rood, JKJ Deegens… - Nephrology Dialysis …, 2012 - academic.oup.com
Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant
nephrotic syndrome in children and adults. Although FSGS is considered a podocyte …

Pathobiology of focal segmental glomerulosclerosis: new developments

VD D'Agati - Current opinion in nephrology and hypertension, 2012 - journals.lww.com
FSGS is caused by a complex interplay of inherent genetic susceptibilities and external
injurious factors acting on podocytes. Critical levels of podocyte stress eventuate in …

Focal segmental glomerulosclerosis and chronic kidney disease in pediatric patients

J Kiffel, Y Rahimzada, H Trachtman - Advances in chronic kidney disease, 2011 - Elsevier
Focal segmental glomerulosclerosis (FSGS) is one of the most common forms of acquired
glomerular disease leading to end-stage kidney disease. Its incidence is rising around the …

Focal and segmental glomerulosclerosis: varying biologic mechanisms underlie a final histopathologic end point

N Daskalakis, MP Winn - Seminars in nephrology, 2006 - Elsevier
Focal and segmental glomerulosclerosis (FSGS) is a pathologic entity that is a common and
increasing cause of end-stage renal disease. Typical manifestations include proteinuria …

New players in the pathogenesis of focal segmental glomerulosclerosis

C Schell, TB Huber - Nephrology Dialysis Transplantation, 2012 - academic.oup.com
Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular
disorder causing end-stage renal disease. Since the first description of this …

Clinical and pathological phenotype of genetic causes of focal segmental glomerulosclerosis in adults

N Lepori, L Zand, S Sethi… - Clinical kidney …, 2018 - academic.oup.com
Focal segmental glomerulosclerosis (FSGS) is a histologic lesion resulting from a variety of
pathogenic processes that cause injury to the podocytes. Recently, mutations in more than …

Secondary focal segmental glomerulosclerosis: from podocyte injury to glomerulosclerosis

JS Kim, BG Han, SO Choi… - BioMed research …, 2016 - Wiley Online Library
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic
syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary …

The pathogenesis of focal segmental glomerulosclerosis

JA Jefferson, SJ Shankland - Advances in chronic kidney disease, 2014 - Elsevier
Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy
that can arise from a diverse range of causes and mechanisms. Although primary and …