Autoantibodies-enemies, and/or potential allies?

H Ma, C Murphy, CE Loscher… - Frontiers in Immunology, 2022 - frontiersin.org
Autoantibodies are well known as potentially highly harmful antibodies which attack the host
via binding to self-antigens, thus causing severe associated diseases and symptoms (eg …

Autoantibody-based diagnostic biomarkers: Technological approaches to discovery and validation

F Aziz, M Smith, JM Blackburn - Autoantibodies and cytokines, 2018 - books.google.com
Autoantibodies produced against self-antigens, or 'autoantigens', result from a loss of
selftolerance triggered by genetic and/or environmental factors which induce the immune …

Toward a new autoantibody diagnostic orthodoxy: understanding the bad, good and indifferent

MJ Fritzler - Autoimmunity Highlights, 2012 - Springer
Rapid advances in diagnostic technologies used to detect autoantibodies have made it
difficult for even the most modern laboratory to keep abreast of the changing approaches …

Autoantibodies targeting intracellular and extracellular proteins in autoimmunity

PD Burbelo, MJ Iadarola, JM Keller… - Frontiers in …, 2021 - frontiersin.org
Detecting autoantibodies provides foundational information for the diagnosis of most
autoimmune diseases. An important pathophysiological distinction is whether …

Definition of human autoimmunity—autoantibodies versus autoimmune disease

A Lleo, P Invernizzi, B Gao, M Podda, ME Gershwin - Autoimmunity reviews, 2010 - Elsevier
The critical function of the immune system is to discriminate self from non-self. Tolerance
against self-antigens is a highly regulated process and, in order to maintain it, the immune …

Autoantibody discovery, assay development and adoption: death valley, the sea of survival and beyond

MJ Fritzler, MY Choi, M Satoh, M Mahler - Frontiers in immunology, 2021 - frontiersin.org
Dating to the discovery of the Lupus Erythematosus (LE) cell in 1948, there has been a
dramatic growth in the discovery of unique autoantibodies and their cognate targets, all of …

Anti-cancer auto-antibodies: Roles, applications and open issues

H de Jonge, L Iamele, M Maggi, G Pessino, C Scotti - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the main causes of death worldwide and early detection
is crucial for effective treatment. Scientists have therefore focused on the identification of …

Autoantibodies 2015: from diagnostic biomarkers toward prediction, prognosis and prevention

J Damoiseaux, LE Andrade, MJ Fritzler… - Autoimmunity reviews, 2015 - Elsevier
Abstract At the 12th International Workshop on Autoantibodies and Autoimmunity (IWAA),
organized in August 2014 in Sao Paulo, Brazil, more than 300 autoimmunologists gathered …

An updated advance of autoantibodies in autoimmune diseases

ZX Xiao, JS Miller, SG Zheng - Autoimmunity reviews, 2021 - Elsevier
Autoantibodies are abnormal antibodies which are generated by pathogenic B cells when
targeting an individual's own tissue. Autoantibodies have been identified as a symbol of …

Mechanisms of autoantibody-induced pathology

RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …