Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …

Type 1 diabetes (T1D) develops when insulin-secreting β-cells, found in the pancreatic islets
of Langerhans, are destroyed by infiltrating T cells. How human T cells recognize β-cell …

Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1
diabetes (T1D) but is also recognized by CD8+ T cells from healthy individuals. We …

Aims/hypothesis Preproinsulin is a target T cell autoantigen in human Type 1 diabetes. This
study analyses the phenotype and epitope recognition of preproinsulin reactive T cells in …

Immunization against insulin, insulin B chain, or B chain peptide B 9–23 (preproinsulin
peptide II 33–47) prevents diabetes in the nonobese diabetic (NOD) mouse. Whether or not …

The autoimmune process that destroys the insulin-producing pancreatic β cells in type 1
diabetes (T1D) is targeted at insulin and its precursor, proinsulin. T cells that recognize the …

A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific
tolerance of T cells. This could suppress autoimmunity in those at risk for the development of …

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells,
found within the islets of Langerhans in the pancreas, are destroyed by islet-infiltrating T …

We investigated the immune response to proinsulin, a potential autoantigen in IDDM
secreted exclusively by pancreatic β-cells. A total of 2,142 short-term cell lines were …