Breakpoint junctions of the chromosomal translocations that occur in human cancers display
hallmarks of nonhomologous end-joining (NHEJ). In mouse cells, translocations are …

Recurrent reciprocal translocations are present in many hematologic and mesenchymal
malignancies. Because significant sequence homology is absent from translocation …

Fusion genes that are caused by chromosome translocations have been recognized for
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …

Chromosomal translocations are very common in human cancer. The molecular
mechanisms of chromosomal translocations are complex and are not fully understood …

Chromosomal translocations in hematologic and mesenchymal tumors form overwhelmingly
by nonhomologous end-joining (NHEJ). Canonical NHEJ, essential for the repair of …

Chromosome translocations are catastrophic genomic events and often play key roles in
tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly …

The finding of acquired chromosomal translocations that are consistently associated with
specific tumour types supports the premise of lineage-specific mechanisms of …

Reciprocal chromosomal translocations are implicated in the etiology of many tumors,
including leukemias, lymphomas, and sarcomas. DNA double-strand breaks (DSBs) caused …

Genetic alterations in DNA can lead to cancer when it is present in proto-oncogenes, tumor
suppressor genes, DNA repair genes etc. Examples of such alterations include deletions …

Although it has been clear for more than a century that the chromosomes in human tumour
cells are often wildly abnormal, there has been controversy as to whether these changes are …