Heterocyclic compounds: pharmacology of pyrazole analogs from rational structural considerations
RF Costa, LC Turones, KVN Cavalcante… - Frontiers in …, 2021 - frontiersin.org
Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
Biologically active pyrazole derivatives
Nitrogen-containing heterocyclic compounds and their derivatives have historically been
invaluable as a source of therapeutic agents. Pyrazole, which has two nitrogen atoms and …
invaluable as a source of therapeutic agents. Pyrazole, which has two nitrogen atoms and …
The therapeutic voyage of pyrazole and its analogs: a review
Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
Synthesis and pharmacological activities of pyrazole derivatives: A review
Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
Pyrazoles as promising scaffold for the synthesis of anti-inflammatory and/or antimicrobial agent: A review
AA Bekhit, A Hymete, EDA Bekhit… - Mini reviews in …, 2010 - ingentaconnect.com
There has been a considerable interest in the development of novel compounds with anti-
inflammatory and/or antimicrobial activities. Several economical and social merits have …
inflammatory and/or antimicrobial activities. Several economical and social merits have …
Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies
G Li, Y Cheng, C Han, C Song, N Huang… - RSC Medicinal …, 2022 - pubs.rsc.org
Pyrazole is a five-membered heterocycle bearing two adjacent nitrogen atoms. Both
pharmaceutical agents and natural products with pyrazole as a nucleus have exhibited a …
pharmaceutical agents and natural products with pyrazole as a nucleus have exhibited a …
Recent advancement in drug design and discovery of pyrazole biomolecules as cancer and inflammation therapeutics
Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is
a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti …
a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti …
Recently reported biological activities of pyrazole compounds
JV Faria, PF Vegi, AGC Miguita, MS Dos Santos… - Bioorganic & medicinal …, 2017 - Elsevier
The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms.
Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved …
Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved …
Amino-pyrazoles in medicinal chemistry: A review
M Lusardi, A Spallarossa, C Brullo - International journal of molecular …, 2023 - mdpi.com
A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …
Consequently, the search for new pyrazole-based compounds is of great interest to the …
A close look into the biological and synthetic aspects of fused pyrazole derivatives
MM Li, H Huang, Y Pu, W Tian, Y Deng, J Lu - European journal of …, 2022 - Elsevier
The fusion of pyrazole scaffold with other skeletons creates a class of attractive molecules,
demonstrating significant biological and chemical potentiality in the development of …
demonstrating significant biological and chemical potentiality in the development of …