The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …

There has been an increased understanding, over the past 2 decades, that asthma is a
chronic, immunologically mediated condition with a disturbance of the normal airway repair …

In addition to its contractile properties, airway smooth muscle may contribute to the
pathogenesis of asthma by increased proliferation, and by the expression and secretion of …

Chronic persistent asthma is characterized by poorly reversible airway obstruction.
Histopathological studies of airways removed postmortem from patients with severe asthma …

Asthma is a disorder of the airways in which Th-2-mediated inflammation is considered to
provide the basis for altered structure and function that leads to bronchial hyper …

Airway smooth muscle plays a multifaceted role in the pathogenesis of asthma. We review
the current understanding of the contribution of airway myocytes to airway inflammation …

Although the pathogenesis of asthma remains unclear, substantial progress has been made
over the past decades in the characterization of airway inflammation as a pathogenetic …

Asthma is defined by three characteristic features, namely, intermittent reversible airway
obstruction, airway hyperresponsiveness, and airway inflammation. Although each of these …

Asthma is a disease characterized, in part, by airway hyperresponsiveness and
inflammation. Although asthma typically induces reversible airway obstruction, in some …

Mucosal inflammation and more recently airway remodeling continue to be a focus of
interest when considering both the pathophysiology and treatment of asthma. Although a …