Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …

Background: FUN14 domain containing 1 (FUNDC1) is a highly conserved outer
mitochondrial membrane protein. The aim of this study is to examine whether FUNDC1 …

Mitochondrial autophagy (or mitophagy) regulates the mitochondrial network and function to
contribute to multiple cellular processes. The protective effect of homeostatic mitophagy in …

Defective mitophagy is causally linked to obesity complications. Here, we identified an
interaction between mitophagy protein FUNDC1 (FUN14 domain containing 1) and receptor …

Aims/hypothesis Diabetic cardiomyopathy, characterised by increased oxidative damage
and mitochondrial dysfunction, contributes to the increased risk of heart failure in individuals …

Mitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete
mitochondria by autophagy, which is critical for the functional integrity of the entire …

Mitochondria are the principal sites of energy metabolism and provide most of the energy
needed for normal cellular function. They are dynamic organelles that constantly undergo …

Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study
investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation …

Disruption of the mitochondrial quality surveillance (MQS) system contributes to
mitochondrial dysfunction in diabetic cardiomyopathy (DCM). In this study, we observed that …

We have recently shown that in diabetic OVE26 mice (type I diabetes), the AMP-activated
protein kinase (AMPK) is reduced along with cardiac dysfunction and decreased cardiac …