Effects of several drugs on the liver injury induced by delayed-type hypersensitivity to picryl chloride by regulating suppressor or helper T cells

J CAO, J LU, F WU, X CHENG, Q XU - Pharmacological research, 1999 - Elsevier
The effects of histamine, cimetidine, and diphenhydramine on picryl chloride (PCl)-induced
ear contact sensitivity, as well as liver injury, were examined in mice. Histamine was found to …

Role of CD4+ and CD8+ T cells in regulating the chronic development of liver injury induced by delayed-type hypersensitivity to picryl chloride

Q Xu, F Wu, J Jiang, J Lu, X Chen… - International archives of …, 1998 - karger.com
In this study we first investigated the cellular immune responses in mice with chronic liver
injury induced by delayed-type hypersensitivity to picryl chloride (PCl). A continuous …

Liver injury model in mice induced by a cellular immunologic mechanism—delayed-type hypersensitivity-induced liver injury to picryl chloride and phenotype of …

Q Xu, R Wang, J Jiang, F Wu, J Lu, PK Tan, L Xu - Cellular immunology, 1996 - Elsevier
Liver injury was induced in BALB/c mice by local delayed-type hypersensitivity (DTH) to
picryl chloride (PCl). Distinct changes of biochemical parameters were observed including …

Liver injury model induced in mice by a cellular immunologic mechanism—study for use in immunopharmacological evaluations

Q XU, J LU, R WANG, F WU, J CAO, X CHEN - Pharmacological research, 1997 - Elsevier
Various drugs for clinical hepatitis were applied to a new model of liver injury induced in
mice by delayed-type hypersensitivity to picryl chloride (PCl-DTH). The hepatoprotective …

Role of Th1 and Th2 cytokines in regulating the liver injury induced by delayed‐type hypersensitivity to picryl chloride

Q Xu, J Cao, F Wu, Y Hayakawa, I Saiki, A Koda - Liver, 1999 - Wiley Online Library
Aims/Background: We have previously reported that a new model of liver injury induced in
mice by delayed‐type hypersensitivity (DTH) to picryl chloride (PCI) mimicks the …

A new strategy for regulating the immunological liver injury—effectiveness of DTH-inhibiting agents on DTH-induced liver injury to picryl chloride

Q XU, K YUAN, J LU, R WANG, F WU - Pharmacological research, 1997 - Elsevier
Aqueous extracts from various crude drugs showing a selective inhibition on the induction or
effector phase of delayed-type hypersensitivity (DTH) reaction were applied to the new …

One-shot delayed-type hypersensitivity reaction in the mouse liver causes a sustained liver injury to picryl chloride

Q Xu, F Wu, B Zhang, J Jiang, J Lu, J Cao, R Wang… - Life sciences, 1997 - Elsevier
The developmental characteristics of liver injury induced by a delayed-type hypersensitivity
(DTH) mechanism against picryl chloride were examined for 9 consecutive weeks in 3 …

Suppression of delayed-type hypersensitivity mediated by macrophage-like cells in mice with experimental liver injury.

S Tajima, N Nishimura, K Ito - Immunology, 1985 - ncbi.nlm.nih.gov
The intensity of picryl chloride-induced delayed-type hypersensitivity (PCl-DTH) was
significantly lowered in mice with experimental liver injury induced by the injection of carbon …

Effect of histamine on delayed-type hypersensitivity in mice

K Tasaka, K Kurokawa, Y Nakayama, M Kakimoto - Immunopharmacology, 1986 - Elsevier
The effect of histamine on delayed-type hypersensitivity provoked in the abdominal cavity of
mice was studied. When histamine (0.1–10 mg/kg) was injected twice a day for 2 …

LFA-1/ICAM-1 interaction is essentially involved in the pathogenesis of delayed-type hypersensitivity-induced liver injury to picryl chloride

X Qiang, J Jieyun, C Jingson, W Feihua, H Fujii, I Saiki - Life Sciences, 1998 - infona.pl
The kinetics of lymphocyte function associated antigen 1 (LFA-1) expression on spleen cells
(SPC) and liver non-parenchymal cells (NPC), and intercellular adhesion molecule 1 (ICAM …