The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and
Map2k2, which encode dual-specificity kinases responsible for ERK activation. Loss of …

Map2k1-/-embryos die at mid-gestation from abnormal development and
hypovascularization of the placenta. We now show that this phenotype is associated with a …

The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and
Map2k2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation …

Background: Extracellular signal‐regulated kinase 2 (ERK2) has been implicated in cell
proliferation, differentiation, and survival. However, its role in vivo remains to be determined …

Mitogen-activated protein kinase (MAP kinase) plays a central role in the signal transduction
for diverse cellular responses, such as proliferation, differentiation, stress response and cell …

Mek is a dual-specificity kinase that activates the extracellular-signal-regulated (Erk)
mitogen-activated protein (MAP) kinases upon agonist binding to receptors. The Erk MAP …

The closely related mitogen‐activated protein kinase isoforms extracellular signal‐regulated
kinase 1 (ERK1) and ERK2 have been implicated in the control of cell proliferation …

Mitogen-activated protein kinases (MAPKs) comprise a family of well-conserved
serine/threonine kinases that control a vast array of physiological functions in a number of …

Differentiation of the mammalian blastocyst generates two distinct cell lineages: the
trophectoderm, which contributes to the trophoblast layers of the placenta, and the inner cell …

ERK1 and ERK2 are the effector kinases of the ERK1/2 MAP-kinase signaling pathway,
which plays a central role in transducing signals controlling cell proliferation, differentiation …