Essential role of the ERK/MAPK pathway in blood-placental barrier formation

V Nadeau, J Charron - Development, 2014 - journals.biologists.com
The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and
Map2k2, which encode dual-specificity kinases responsible for ERK activation. Loss of …

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis

V Bissonauth, S Roy, M Gravel, S Guillemette… - 2006 - journals.biologists.com
Map2k1-/-embryos die at mid-gestation from abnormal development and
hypovascularization of the placenta. We now show that this phenotype is associated with a …

Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation

V Nadeau, S Guillemette, LF Bélanger, O Jacob, S Roy… - 2009 - journals.biologists.com
The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and
Map2k2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation …

Essential role for ERK2 mitogen‐activated protein kinase in placental development

N Hatano, Y Mori, M Oh‐hora, A Kosugi… - Genes to …, 2003 - Wiley Online Library
Background: Extracellular signal‐regulated kinase 2 (ERK2) has been implicated in cell
proliferation, differentiation, and survival. However, its role in vivo remains to be determined …

Expression and activation of MAP kinases, ERK1/2, in the human villous trophoblasts

N Kita, J Mitsushita, S Ohira, Y Takagi, T Ashida… - Placenta, 2003 - Elsevier
Mitogen-activated protein kinase (MAP kinase) plays a central role in the signal transduction
for diverse cellular responses, such as proliferation, differentiation, stress response and cell …

[PDF][PDF] Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

S Giroux, M Tremblay, D Bernard, JF Cardin-Girard… - Current Biology, 1999 - cell.com
Mek is a dual-specificity kinase that activates the extracellular-signal-regulated (Erk)
mitogen-activated protein (MAP) kinases upon agonist binding to receptors. The Erk MAP …

An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development

MK Saba‐El‐Leil, FDJ Vella, B Vernay, L Voisin… - EMBO …, 2003 - embopress.org
The closely related mitogen‐activated protein kinase isoforms extracellular signal‐regulated
kinase 1 (ERK1) and ERK2 have been implicated in the control of cell proliferation …

Functions of MAP kinases: insights from gene-targeting studies

K Kuida, DM Boucher - Journal of biochemistry, 2004 - academic.oup.com
Mitogen-activated protein kinases (MAPKs) comprise a family of well-conserved
serine/threonine kinases that control a vast array of physiological functions in a number of …

[PDF][PDF] Erk2 signaling and early embryo stem cell self-renewal

S Meloche, FDJ Vella, L Voisin, SL Ang… - Cell cycle, 2004 - Taylor & Francis
Differentiation of the mammalian blastocyst generates two distinct cell lineages: the
trophectoderm, which contributes to the trophoblast layers of the placenta, and the inner cell …

[PDF][PDF] Functional redundancy of ERK1 and ERK2 MAP kinases during development

C Fremin, MK Saba-El-Leil, K Levesque, SL Ang… - Cell reports, 2015 - cell.com
ERK1 and ERK2 are the effector kinases of the ERK1/2 MAP-kinase signaling pathway,
which plays a central role in transducing signals controlling cell proliferation, differentiation …