Interactions between immune and malignant cells have been known to have clinical
relevance for decades. The potential for immune control is now being therapeutically …

Tumour immunotherapy has achieved remarkable clinical success in many different types of
cancer in the past two decades. The outcome of immune checkpoint inhibitors in cancer …

The tumor immune contexture plays a major role for the clinical outcome of patients. High
densities of CD45RO+ T helper 1 cells and CD8+ T cells are associated with improved …

Leukocyte infiltrates into or around tumor cell nests are found in the context of
protumorigenic inflammation and anticancer immunosurveillance. Hence, the detailed …

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels,
cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating …

In the recent years, breakthrough advances in the characterization of the tumor-infiltrating
immune cells and in the understanding of their influence on tumor invasion and metastasis …

Solid tumors are constituted of a variety of cellular components, including bona fide
malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor …

The interplay between tumors and their immunologic microenvironment is complex and
difficult to decipher, but its understanding is of seminal importance for the development of …

Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Components of the cellular and the humoral arm of the immune system are essential
elements of the tumour microenvironment (TME). The TME includes tumour‐associated …