Growth hormone (GH) is a polypeptide hormone that could reduce the mitochondria-
mediated oxidative stress and improve the mitochondrial function. However, the …

High mitochondrial oxidative phosphorylation (mt-OXPHOS) levels are required to supply
the ATP necessary for follicle-stimulating hormone (FSH)-induced granulosa cell …

Premature ovarian insufficiency (POI) is a heterogeneous disorder and lacks effective
interventions in clinical applications. This research aimed to elucidate the potential effects of …

Oxidative-stress-induced apoptosis of granulosa cells is considered to be a main driver of
follicular atresia. Increasing evidence suggests a protective effect of melatonin against …

Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also
induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity …

Genistein is an isoflavone that has estrogen (E2)‐like activity and is beneficial for follicular
development, but little is known regarding its function in oxidative stress (OS)‐mediated …

Disrupted follicular development may result in increased follicular atresia, which is a crucial
mechanism of various ovarian pathologies. It has been demonstrated that oxidative stress is …

Previous evidences have indicated that granulosa cells play a critical role in follicular
growth. Hydrogen peroxide (H2O2)-induced oxidative stress has been associated with …

Ovarian follicle steroidogenesis associated with embryo quality results in a successful
pregnancy. Each follicle consists of an oocyte surrounded by granulosa cells, which secrete …

Objective We examined rat ovarian granulosa cells at different follicular stages and
evaluated the apoptosis pattern of the mitochondria-dependent genes during …