Sono‐Driven STING Activation using Semiconducting Polymeric Nanoagonists for Precision Sono‐Immunotherapy of Head and Neck Squamous Cell Carcinoma

J Jiang, M Zhang, T Lyu, L Chen, M Wu, R Li… - Advanced …, 2023 - Wiley Online Library
Immunotherapy has offered new opportunities to treat head and neck squamous cell
carcinoma (HNSCC); however, its clinical applications are hindered by modest therapeutic …

Polymeric STING Pro‐agonists for Tumor‐Specific Sonodynamic Immunotherapy

J Yu, S He, C Zhang, C Xu, J Huang, M Xu… - Angewandte …, 2023 - Wiley Online Library
The efficacy of combination immunotherapy has been limited by tumor specificity and
immune‐related adverse events (irAEs). Herein, we report the development of polymeric …

Augmenting Immunogenic Cell Death and Alleviating Myeloid‐Derived Suppressor Cells by Sono‐Activatable Semiconducting Polymer Nanopartners for …

M Ding, Y Zhang, N Yu, J Zhou, L Zhu… - Advanced …, 2023 - Wiley Online Library
Inducing immunogenic cell death (ICD) by sonodynamic therapy (SDT) is promising for
cancer immunotherapy, which however is inefficient due to oxygen depletion that …

Immunogenic nanomedicine based on GSH-responsive nanoscale covalent organic polymers for chemo-sonodynamic therapy

F Shen, D Tao, R Peng, Y He, Z Liu, J Ji, L Feng - Biomaterials, 2022 - Elsevier
Sonodynamic therapy (SDT) is emerging as a non-invasive strategy to eradicate tumors, but
its therapeutic efficacy is still not ideal. To achieve more effective SDT, water insoluble …

[HTML][HTML] Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

J Li, Y Luo, Z Zeng, D Cui, J Huang, C Xu, L Li… - Nature …, 2022 - nature.com
Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to
elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to …

Activatable cancer sono‐immunotherapy using semiconducting polymer nanobodies

Z Zeng, C Zhang, S He, J Li, K Pu - Advanced Materials, 2022 - Wiley Online Library
Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its
clinical applications are hindered by the “always‐on” pharmacological activities of …

Dual-modulation of immunosuppressive pathways using sono-activatable semiconducting polymer nanofeedbacks for cancer immunotherapy

N Yu, M Li, Y Zhang, F Wang, X Yu, R Cai, J Li - Nano Today, 2023 - Elsevier
Although the combinations of immunotherapy with other therapies can offer promising
possibility to sensitize tumors to various immunotherapeutic strategies for amplified …

Sonodynamic amplification of cGAS-STING activation by cobalt-based nanoagonist against bone and metastatic tumor

J Lei, W Zhang, L Ma, Y He, H Liang, X Zhang, G Li… - Biomaterials, 2023 - Elsevier
The therapeutic effect of cancer immunotherapy is restrained by limited patient response
rate caused by 'cold'tumors with an intrinsically immunosuppressive tumor …

Bioactivable STING Nanoagonists to Synergize NIR‐II Mild Photothermal Therapy Primed Robust and Long‐Term Anticancer Immunity

W Ma, R Sun, L Tang, Z Li, L Lin, Z Mai… - Advanced …, 2023 - Wiley Online Library
Pharmacological activation of the stimulator of interferon genes (STING) pathway has
become a promising strategy for cancer immunotherapy. However, the insufficient tumorous …

Organic sonodynamic materials for combination cancer immunotherapy

C Zhang, K Pu - Advanced Materials, 2023 - Wiley Online Library
Sonodynamic therapy (SDT) is a promising non‐invasive therapeutic modality to treat deep‐
seated tumors owing to the good tissue penetration ability and spatiotemporal controllability …