Sono‐Driven STING Activation using Semiconducting Polymeric Nanoagonists for Precision Sono‐Immunotherapy of Head and Neck Squamous Cell Carcinoma
J Jiang, M Zhang, T Lyu, L Chen, M Wu, R Li… - Advanced …, 2023 - Wiley Online Library
Immunotherapy has offered new opportunities to treat head and neck squamous cell
carcinoma (HNSCC); however, its clinical applications are hindered by modest therapeutic …
carcinoma (HNSCC); however, its clinical applications are hindered by modest therapeutic …
Polymeric STING Pro‐agonists for Tumor‐Specific Sonodynamic Immunotherapy
The efficacy of combination immunotherapy has been limited by tumor specificity and
immune‐related adverse events (irAEs). Herein, we report the development of polymeric …
immune‐related adverse events (irAEs). Herein, we report the development of polymeric …
Augmenting Immunogenic Cell Death and Alleviating Myeloid‐Derived Suppressor Cells by Sono‐Activatable Semiconducting Polymer Nanopartners for …
M Ding, Y Zhang, N Yu, J Zhou, L Zhu… - Advanced …, 2023 - Wiley Online Library
Inducing immunogenic cell death (ICD) by sonodynamic therapy (SDT) is promising for
cancer immunotherapy, which however is inefficient due to oxygen depletion that …
cancer immunotherapy, which however is inefficient due to oxygen depletion that …
Immunogenic nanomedicine based on GSH-responsive nanoscale covalent organic polymers for chemo-sonodynamic therapy
Sonodynamic therapy (SDT) is emerging as a non-invasive strategy to eradicate tumors, but
its therapeutic efficacy is still not ideal. To achieve more effective SDT, water insoluble …
its therapeutic efficacy is still not ideal. To achieve more effective SDT, water insoluble …
[HTML][HTML] Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles
Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to
elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to …
elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to …
Activatable cancer sono‐immunotherapy using semiconducting polymer nanobodies
Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its
clinical applications are hindered by the “always‐on” pharmacological activities of …
clinical applications are hindered by the “always‐on” pharmacological activities of …
Dual-modulation of immunosuppressive pathways using sono-activatable semiconducting polymer nanofeedbacks for cancer immunotherapy
Although the combinations of immunotherapy with other therapies can offer promising
possibility to sensitize tumors to various immunotherapeutic strategies for amplified …
possibility to sensitize tumors to various immunotherapeutic strategies for amplified …
Sonodynamic amplification of cGAS-STING activation by cobalt-based nanoagonist against bone and metastatic tumor
The therapeutic effect of cancer immunotherapy is restrained by limited patient response
rate caused by 'cold'tumors with an intrinsically immunosuppressive tumor …
rate caused by 'cold'tumors with an intrinsically immunosuppressive tumor …
Bioactivable STING Nanoagonists to Synergize NIR‐II Mild Photothermal Therapy Primed Robust and Long‐Term Anticancer Immunity
W Ma, R Sun, L Tang, Z Li, L Lin, Z Mai… - Advanced …, 2023 - Wiley Online Library
Pharmacological activation of the stimulator of interferon genes (STING) pathway has
become a promising strategy for cancer immunotherapy. However, the insufficient tumorous …
become a promising strategy for cancer immunotherapy. However, the insufficient tumorous …
Organic sonodynamic materials for combination cancer immunotherapy
C Zhang, K Pu - Advanced Materials, 2023 - Wiley Online Library
Sonodynamic therapy (SDT) is a promising non‐invasive therapeutic modality to treat deep‐
seated tumors owing to the good tissue penetration ability and spatiotemporal controllability …
seated tumors owing to the good tissue penetration ability and spatiotemporal controllability …