Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …

Simple Summary Hypoxia is a common feature of lung cancers. Nonetheless, no guidelines
have been established to integrate hypoxia-associated biomarkers in patient management …

Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital
role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia …

Purpose Tumor hypoxia correlates with treatment failure in patients undergoing
conventional radiation therapy. However, no published studies have investigated tumor …

Tumor hypoxia has been found to be a characteristic feature in lung cancer. It has been
shown to decrease the therapeutic efficacy of radiotherapy and some forms of …

Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …

Since observations from the beginning of the last century, it has become well established
that solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas …

Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …