Hypoxia as a cause of treatment failure in non–small cell carcinoma of the lung
OT Brustugun - Seminars in radiation oncology, 2015 - Elsevier
Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …
Hypoxia in lung cancer management: a translational approach
J Ancel, JM Perotin, M Dewolf, C Launois, P Mulette… - Cancers, 2021 - mdpi.com
Simple Summary Hypoxia is a common feature of lung cancers. Nonetheless, no guidelines
have been established to integrate hypoxia-associated biomarkers in patient management …
have been established to integrate hypoxia-associated biomarkers in patient management …
How the histological structure of some lung cancers shaped almost 70 years of radiobiology
KR Worth, I Papandreou, EM Hammond - British Journal of Cancer, 2023 - nature.com
Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital
role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia …
role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia …
High single doses of radiation may induce elevated levels of hypoxia in early-stage non-small cell lung cancer tumors
Purpose Tumor hypoxia correlates with treatment failure in patients undergoing
conventional radiation therapy. However, no published studies have investigated tumor …
conventional radiation therapy. However, no published studies have investigated tumor …
Implementation of hypoxia measurement into lung cancer therapy
X Meng, J Yu - Lung Cancer, 2012 - Elsevier
Tumor hypoxia has been found to be a characteristic feature in lung cancer. It has been
shown to decrease the therapeutic efficacy of radiotherapy and some forms of …
shown to decrease the therapeutic efficacy of radiotherapy and some forms of …
The clinical significance of hypoxia in human cancers
N Dhani, A Fyles, D Hedley, M Milosevic - Seminars in nuclear medicine, 2015 - Elsevier
Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …
Hypoxia and radiation therapy: past history, ongoing research, and future promise
S Rockwell, IT Dobrucki, EY Kim… - Current molecular …, 2009 - ingentaconnect.com
Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …
Hypoxic radiosensitization: adored and ignored
J Overgaard - Journal of Clinical Oncology, 2007 - ascopubs.org
Since observations from the beginning of the last century, it has become well established
that solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas …
that solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas …
Targeting hypoxia to improve non–small cell lung cancer outcome
A Salem, MC Asselin, B Reymen… - JNCI: Journal of the …, 2018 - academic.oup.com
Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …
The impact of hypoxia and its modification of the outcome of radiotherapy
MR Horsman, J Overgaard - Journal of radiation research, 2016 - academic.oup.com
Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …