Nucleoside/nucleobase analogs (bromodeoxyuridine, iododeoxyuridine, 5fluorouracil,
fluorodeoxyuridine, difluorodeoxycytidine, fluoroadenine arabinoside …

Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce
substantial sensitization of tumor cells to radiation treatment. The process is called …

The available knowledge on potential radiosensitizing nucleoside analogues with special
focus on fludarabine and gemcitabine is reviewed. These analogues are prodrugs whose …

The halogenated pyrimidine, fluorodeoxyuridine (FdUrd), has been used in combination
with radiation for the treatment of human neoplasms. In an attempt to improve the clinical …

The biomodulators leucovorin and dipyridamole potentiate the cytotoxicity of 5-
fluorodeoxyuridine (FdUrd) and 5-fluorouracil (5-FU), respectively. It was hypothesized that …

This chapter outlines the available knowledge on radiosensitization by arabinosylpurine and
arabinosylpyrimidine nucleoside analogs. A variety of experimental studies have …

Radiosensitization with antimetabolites has improved clinical outcome for patients with solid
malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil …

Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce
substantial sensitization of tumor cells to radiation treament. The clinical effectiveness of …

Abstract (E)-2′-Deoxy-(fluoromethylene) cytidine (FMdC) is known as an inhibitor of
ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA …

Radiotherapy and chemotherapy are often administered concurrently in an attempt to take
advantage of postulated biochemical or molecular interactions between the two modalities. It …