[HTML][HTML] Angiogenic signaling pathways and anti-angiogenic therapy for cancer

ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy

Z Wang, C Dabrosin, X Yin, MM Fuster, A Arreola… - Seminars in cancer …, 2015 - Elsevier
Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

[HTML][HTML] Tumor neovascularization and developments in therapeutics

Y Katayama, J Uchino, Y Chihara, N Tamiya, Y Kaneko… - Cancers, 2019 - mdpi.com
Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

Tumor angiogenesis revisited: regulators and clinical implications

R Ronca, M Benkheil, S Mitola, S Struyf… - Medicinal research …, 2017 - Wiley Online Library
Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy

A Abdollahi, J Folkman - Drug Resistance Updates, 2010 - Elsevier
Within three decades, anti-angiogenic therapy has rapidly evolved into an integral
component of current standard anti-cancer treatment. Anti-angiogenic therapy has fulfilled a …

[HTML][HTML] The role of angiogenesis in cancer treatment

M Rajabi, SA Mousa - Biomedicines, 2017 - mdpi.com
A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …

[HTML][HTML] Angiogenesis: managing the culprits behind tumorigenesis and metastasis

AHS Yehya, M Asif, SH Petersen, AV Subramaniam… - Medicina, 2018 - mdpi.com
Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …

Antiangiogenic therapies: going beyond their limits

L Moserle, G Jiménez-Valerio, O Casanovas - Cancer discovery, 2014 - AACR
Tumor growth requires induction of an angiogenic program, and targeting of this program
with antiangiogenic drugs shows an impact on tumor progression. However, although they …

[PDF][PDF] Exploring novel methods for modulating tumor blood vessels in cancer treatment

PP Wong, N Bodrug, KM Hodivala-Dilke - Current biology, 2016 - cell.com
Several studies have explored the potential of targeting tumor angiogenesis in cancer
treatment. Anti-angiogenesis monotherapy, which reduces blood vessel numbers, may still …

Angiogenesis modulation in cancer research: novel clinical approaches

M Cristofanilli, C Charnsangavej… - Nature reviews Drug …, 2002 - nature.com
Angiogenesis—the formation of new blood vessels—is essential for tumour progression and
metastasis. Consequently, the modulation of tumour angiogenesis using novel agents has …