Prognostic utility of BRAF mutation in papillary thyroid cancer

M Xing - Molecular and cellular endocrinology, 2010 - Elsevier
Papillary thyroid cancer (PTC) is a common endocrine malignancy that frequently harbors
the oncogenic T1799A BRAF mutation. As a novel prognostic molecular marker, this …

BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer

M Xing, WH Westra, RP Tufano, Y Cohen… - The Journal of …, 2005 - academic.oup.com
Context: Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve
risk stratification of this cancer. Objective: The objective of the study was to investigate the …

BRAF mutation is not predictive of long‐term outcome in papillary thyroid carcinoma

LE Henke, JD Pfeifer, C Ma, SM Perkins… - Cancer …, 2015 - Wiley Online Library
The BRAF mutation occurs commonly in papillary thyroid carcinoma (PTC). Previous
investigations of its utility to predict recurrence‐free survival (RFS) and disease‐specific …

BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

Clinical Significance of BRAF Mutation in Thyroid Papillary Cancer

IJ Fernandez, O Piccin, S Sciascia… - … –Head and Neck …, 2013 - journals.sagepub.com
Objective To correlate the presence of BRAF V600E mutation with clinicopathological
parameters. Study Design Case-control study. Setting BRAF mutation represents the most …

Clinicopathologic Implications of the BRAFV600E Mutation in Papillary Thyroid Cancer: A Subgroup Analysis of 3130 Cases in a Single Center

JY Lim, SW Hong, YS Lee, BW Kim, CS Park… - Thyroid, 2013 - liebertpub.com
Background: The BRAF mutation has been shown to be associated with aggressive
clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies …

Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma

C Lupi, R Giannini, C Ugolini, A Proietti… - The Journal of …, 2007 - academic.oup.com
Context: Because very few studies have examined the correlation between BRAF mutations
and clinicopathological features of papillary thyroid carcinoma (PTC), we analyzed here a …

Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation

L Yip, MN Nikiforova, SE Carty, JH Yim, MT Stang… - Surgery, 2009 - Elsevier
BACKGROUND: To date, a mutation of the BRAF oncogene is the most common genetic
alteration found in papillary thyroid carcinoma (PTC) and is associated with extrathyroidal …

Lack of association of BRAF mutation with negative prognostic indicators in papillary thyroid carcinoma: the University of California, San Francisco, experience

C Gouveia, NT Can, A Bostrom… - … –head & neck …, 2013 - jamanetwork.com
Importance Papillary thyroid carcinoma (PTC) is the most common endocrine neoplasm. B-
type raf kinase (BRAF) V600E mutation has been proposed as a negative prognostic …

Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions

D Handkiewicz-Junak, A Czarniecka… - Molecular and cellular …, 2010 - Elsevier
Gene expression profiling shows that, by gene signature, the difference between BRAF-
positive and BRAF-negative PTC is so distinct that BRAF-positive cancer may be regarded …