114 Biol Res 28: 113-125 (1995) controls may play a physiological role in the detection of
nociceptive signals. It is proposed that DNIC constitute both a filter which allows the …

Publisher Summary This chapter presents the electrophysiological evidence for the
activation of descending inhibitory controls by nociceptive afferent pathways. The three …

Fifty-eight lumbar dorsal horn and trigeminal nucleus caudalis neurones which could be
activated by both innocuous and noxious peripheral stimuli have been recorded in the …

In normal subjects, heterotopic painful stimuli induce simultaneous and parallel decreases
in the sensation of pain and in the spinal nociceptive flexion (RIII) reflex evoked by electrical …

The effect of exogenous opiates upon diffuse noxious inhibitory controls (DNIC) was
investigated in intact anaesthetized rats. 58 convergent neurones, responding to both …

It has previously been shown that, in normal subjects, heterotopic painful stimuli induce
parallel decreases in the sensation of pain and the nociceptive spinal flexion reflex RIII …

Ever since Le Bars et al. 21 detailed in 1979 that “the activity of convergent dorsal horn
neurons could be powerfully inhibited by noxious stimuli applied to various parts of the …

1. Noxious stimuli have been shown to produce a diffuse inhibition of nociresponsive
neurons in the spinal and trigeminal dorsal horns. The present study sought to extend these …

Some neurones in the dorsal horn of the spinal cord are strongly inhibited when a
nociceptive stimulus is applied to any part of the body, distinct from their excitatory receptive …

Central nervous system (CNS) mechanisms of pain processing do not consist only of a
bottom-up process whereby a painful focus modifies the inputs to the next higher level. In …