Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

In this review, we summarise the function and structure of telomerase reverse transcriptase
(TERT) in humans, including its regulation. The dysregulation of telomerase through TERT …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Telomerase, an RNA-dependent DNA polymerase with telomerase reverse transcriptase
(TERT) as the catalytic component, is silent due to the tight repression of the TERT gene in …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

Activation of telomerase is a critical step in the development of about 85% of human
cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are …

Telomerase activity is critical for cancer cells to provide unrestricted proliferation and cellular
immortality through maintaining telomeres. Telomerase enzymatic activity is regulatable at …

Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining
genome integrity, controlling cell proliferation, and regulating tissue homeostasis …

Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division.
This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; …