Acetylcholine (ACh) is an important neuromodulator in the nervous system implicated in
many forms of cognitive and motor processing. Recent studies have used bacterial artificial …

Defining the contribution of acetylcholine to specific behaviors has been challenging, mainly
because of the difficulty in generating suitable animal models of cholinergic dysfunction. We …

Storage of acetylcholine in synaptic vesicles plays a key role in maintaining cholinergic
function. Here we used mice with a targeted mutation in the vesicular acetylcholine …

Cholinergic neurotransmission in the hippocampus is involved in cognitive functions,
including learning and memory. Strategies to enhance septohippocampal cholinergic …

An important step for cholinergic transmission involves the vesicular storage of acetylcholine
(ACh), a process mediated by the vesicular acetylcholine transporter (VAChT). In order to …

Cholinergic neurotransmission supports motor, autonomic, and cognitive function and is
compromised in myasthenias, cardiovascular diseases, and neurodegenerative disorders …

The vesicular acetylcholine (ACh) transporter (VAChT) mediates ACh storage by synaptic
vesicles. However, the VAChT-independent release of ACh is believed to be important …

THE organization of the mouse choline acetyltransferase (ChAT) gene has been previously
analyzed. Here we show that the first intron of the mouse ChAT gene contains an …

Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of
neurodegenerative and neuropsychiatric diseases. Here we tested how information …

Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter
acetylcholine (ACh), is thought to be present in kinetic excess in cholinergic neurons. The …