ABSTRACT DNA methylation (DNAm) is one of the most studied epigenetic modifications.
DNAm has emerged as a key biological mechanism and biomarkers to test associations …

Abstract Purpose of Review This manuscript orients the reader to the underlying motivations
of environmental biomarker development for human population studies and provides the …

Epigenetic changes represent a potential mechanism underlying associations of early-life
exposures and later life health outcomes. Population-based cohort studies starting in early …

DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …

DNA methylation (DNAm) is an essential epigenetic mechanism for normal development,
and its variation may be associated with diseases. High-throughput technology allows …

Air pollution exposure is estimated to contribute to approximately seven million early deaths
every year worldwide and more than 3% of disability-adjusted life years lost. Air pollution …

Abstract Purpose of Review This review demonstrates the growing body of evidence
connecting DNA methylation to prior exposure. It highlights the potential to use DNA …

Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in
peripheral tissues such as whole blood to identify positions in the genome where variation is …

Objective Health or disease is shaped for all individuals by interactions between their genes
and environment. Exactly how the environment changes gene expression and how this can …

Purpose of Review DNA methylation-based aging biomarkers are valuable tools for
evaluating the aging process from a molecular perspective. These epigenetic aging …