Alveolar macrophages, resident phagocytic cells in the lung that derive from peripheral
blood monocytes, are paradoxically ineffective in presenting antigen to T cells. We found …

Activation of naive T cells requires at least two signals. In addition to the well characterized
interaction of the T cell antigen receptor with the antigen/MHC expressed on an antigen …

Tissue structural cells are known in some situations to play a role in the presentation of
antigen and in immunoregulation. We assessed the expression of B7 homologs, known to …

The murine B7 (mB7) protein is a potent costimulatory molecule for the T-cell receptor (TCR)-
mediated activation of murine CD4+ T cells. We have previously shown that stable mB7 …

Background: Alveolar macrophages (AMs) are more efficient antigen-presenting cells in
allergic individuals than in nonatopic subjects. Objective: We studied whether this difference …

CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which
bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons …

Human lung alveolar epithelial cells constitutively express class II major histocompatibility
complex (MHC). Human lung microvascular endothelial and small airway epithelial cells can …

The molecular events that modulate the T-cell response to antigen are key determinants in
the outcome of pulmonary immune responses. Over the past several years, it has become …

A class of molecules that is expressed on antigen presenting cells, exemplified by CD80
(B7), has been found to provide a necessary costimulatory signal for T cell activation and …

B7-2 is a recently discovered, second ligand for the CTLA-4/CD28, T cell signaling system.
Using the GL-1 rat monoclonal antibody (mAb), we monitored expression of B7-2 on mouse …