Understanding latent tuberculosis: a moving target

PL Lin, JAL Flynn - The Journal of Immunology, 2010 - journals.aai.org
Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

Mycobacterium tuberculosis: immune evasion, latency and reactivation

A Gupta, A Kaul, AG Tsolaki, U Kishore, S Bhakta - Immunobiology, 2012 - Elsevier
One-third of the global human population harbours Mycobacterium tuberculosis in dormant
form. This dormant or latent infection presents a major challenge for global efforts to …

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

CE Barry 3rd, HI Boshoff, V Dartois, T Dick… - Nature Reviews …, 2009 - nature.com
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Tuberculosis: latency and reactivation

JAL Flynn, J Chan - Infection and immunity, 2001 - Am Soc Microbiol
Tuberculosis is a major cause of death around the world, with most of the 1.5 million deaths
per year attributable to the disease occurring in developing countries. This disease is …

Tuberculosis: an infection-initiated autoimmune disease?

P Elkington, M Tebruegge, S Mansour - Trends in immunology, 2016 - cell.com
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and provided original
proof that an infectious agent can cause human disease. However, key steps in TB …

The end of the binary era: revisiting the spectrum of tuberculosis

PL Lin, JAL Flynn - The Journal of Immunology, 2018 - journals.aai.org
Human Mycobacterium tuberculosis infection was thought to result in either active
symptomatic tuberculosis (TB) or latent asymptomatic infection. It is now clear that this binary …

Latent tuberculosis: what the host “sees”?

HP Gideon, JAL Flynn - Immunologic research, 2011 - Springer
Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), is the most
successful pathogen of mankind and remains a major threat to global health as the leading …

Diagnosis and management of latent tuberculosis infection

L Muñoz, HR Stagg, I Abubakar - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The post-2015 World Health Organization global tuberculosis strategy recognizes that
elimination requires a focus on reducing the pool of latently infected individuals, an …

Human immunology of tuberculosis

TJ Scriba, AK Coussens, HA Fletcher - Microbiology spectrum, 2017 - Am Soc Microbiol
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …

[HTML][HTML] The knowns and unknowns of latent Mycobacterium tuberculosis infection

WH Boom, UE Schaible… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …