Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea
hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …

Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

OSA is a heterogeneous disease with highly varying underlying mechanisms. OSA has
variable clinical manifestations with definable subsets having risk of particular …

Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

Introduction: Obstructive sleep apnea (OSA) is a serious and prevalent medical condition
with major consequences for health and safety. Excessive daytime sleepiness (EDS) is a …

Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Obstructive sleep apnea (OSA) is thought to affect almost 1 billion people worldwide. OSA
has well established cardiovascular and neurocognitive sequelae, although the optimal …

Background and objective To personalize OSA management, several studies have
attempted to better capture disease heterogeneity by clustering methods. The aim of this …

Rationale: There are at least four key pathophysiological endotypes that contribute to
obstructive sleep apnea (OSA) pathophysiology. These include 1) upper-airway …