The United States is entering its fourth decade of the opioid epidemic with no clear end in
sight. At the center of the epidemic is an increase in opioid use disorder (OUD), a complex …

The mainstay of treatment for opioid use disorder (OUD) is opioid agonist therapy (OAT),
which modulates opioid receptors to reduce substance craving and use. OAT maintains …

Background: Opioid use disorders (OUD) translate into major health, social, and economic
consequences. Opioid agonist medications, which generally require long-term …

Opioid use disorder is a major public health crisis that is manifested by persistent drug-
seeking behavior and high relapse frequency. Most of the available treatments rely on …

Ibogaine is a powerful psychoactive substance that not only alters perception, mood and
affect, but also stops addictive behaviors. Ibogaine has a very long history of ethnobotanical …

Disrupted mental health affects up to one in three individuals globally and is an unmet
medical challenge contributing to individual suffering as well as significant societal and …

Addiction is best described as a disorder of maladaptive neuroplasticity involving the
simultaneous strengthening of reward circuitry that drives compulsive drug seeking and …

Ibogaine is a naturally occurring psychedelic medicine with anti-addictive properties. While
research on ibogaine is limited, several observational studies have shown ibogaine can …

Even as prescription opioid dispensing rates have begun to decrease, the use of illicit
opioids such as heroin and fentanyl has increased. Thus, the end of the opioid epidemic is …

Ibogaine is an indole alkaloid that comes from the root of the West African shrub
Tabernanthe iboga. Ibogaine has been used for centuries in spiritual celebrations, coming of …