Abstract Effects of d (CAG) n· d (CTG) n repeats on expression of a reporter gene in human
cell culture were studied using transient transfection, RNase protection and coupled …

Trinucleotide repeats (TNRs) undergo frequent mutations in families affected by TNR
diseases and in model organisms. Much of the instability is conferred in cis by the sequence …

Myotonic dystrophy (DM) is a dominant neuromuscular disorder caused by the expansion of
trinucleotide CTG repeats in the 3-untranslated region (3′-UTR) of the MtPK gene …

The relative ability of the 10 triplet repeat sequences to be expanded in Escherichia coli was
determined. Surprisingly, CTG tracts are expanded at least 8 times more frequently than any …

Transcription stimulates the genetic instability of trinucleotide repeat sequences. However,
the mechanisms leading to transcription-dependent repeat length variation are unclear. We …

Despite substantial progress in understanding the mechanism by which expanded
CTG/CAG trinucleotide repeats cause neurodegenerative diseases, little is known about the …

We describe conditions for producing uninterrupted expanded CTG repeats consisting of up
to 2000 repeats using ϕ29 DNA polymerase. Previously, generation of such repeats was …

Several human hereditary neuromuscular and neurodegenerative diseases are caused by
abnormal expansion of triplet repeat sequences (TRSs) CAG/CTG, CGG/CCG, or GAA/TTC …

We have compared the effect of 3′ context on the efficiency of nonsense suppressor tRNAs
in Escherichia coli and human cells. Plasmids containing amber (UAG) termination codons …

Trinucleotide repeat expansion is the causative mutation for a growing number of diseases
including myotonic dystrophy, Huntington's disease, and fragile X syndrome. A (CTG/CAG) …