Context The rapid pubertal height growth is unique to humans, but why do we have it?
Although the spurt contributes 13% to 15% to the final adult height, we hypothesized that the …

Human growth is a complex process starting at conception and completing in adolescence
at the time of growth plate fusion. Growth can be divided into four phases:(1) fetal, where the …

Objective Pubertal gynaecomastia is a very common condition. Although the underlying
aetiology is poorly understood, it is generally accepted that excess of oestrogens and deficit …

It has been suggested that growth hormone (GH) may play a regulatory role in male
reproductive function. To express full anabolic effect in immature boys testosterone …

We tested the hypothesis that growth hormone (GH) mediates the rise in insulin-like growth
factor I (IGF-I) concentrations in children with precocious puberty. We studied three groups of …

Background The hypothalamic‐pituitary‐gonadal (HPG) and hypothalamic‐pituitary‐
somatotropic (HPS) axes are strongly interconnected. Interactions between these axes are …

Objective IGF1 plays an important role in growth and metabolism during puberty. IGF1 levels
are increased in girls with central precocious puberty (CPP). However, the relationship with …

Summary OBJECTIVE IGF‐I rises in normal adolescence and in central precocious puberty
(CPP), secondary to a rise in sex steroids and GH. The aim of this study was to examine …

Given the tight, temporal coupling between growth and reproductive development, the idea
that a common signal may regulate both adolescent growth and the initiation of puberty has …

OBJECTIVE The pathophysiological mechanisms underlying the failure of catch up‐growth
in children with short stature after Intrauterine growth retardation (IUGR) remain obscure …