S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma
D Basavarajappa, V Gupta, R Vander Wall… - FASEB …, 2023 - researchers.mq.edu.au
Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …
[HTML][HTML] Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma
D Basavarajappa, V Gupta, N Chitranshi… - Neural Regeneration …, 2023 - journals.lww.com
Abstract Sphingosine-1-phosphate receptor (S1PR) signaling regulates diverse
pathophysiological processes in the central nervous system. The role of S1PR signaling in …
pathophysiological processes in the central nervous system. The role of S1PR signaling in …
[HTML][HTML] Anti-inflammatory effects of siponimod in a mouse model of excitotoxicity-induced retinal injury
D Basavarajappa, V Gupta, N Chitranshi… - Molecular …, 2023 - Springer
Glaucoma is a leading cause of permanent blindness worldwide and is characterized by
neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage …
neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage …
Sphingosine 1‐phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma
In this study, we used a classical optic nerve injury model to address the function of the
sphingosine 1‐phosphate (S1P)–S1P receptor (S1PR) axis in retinal ganglion cell (RGC) …
sphingosine 1‐phosphate (S1P)–S1P receptor (S1PR) axis in retinal ganglion cell (RGC) …
[HTML][HTML] Characterizing sphingosine kinases and sphingosine 1-phosphate receptors in the mammalian eye and retina
H Porter, H Qi, N Prabhu, R Grambergs… - International Journal of …, 2018 - mdpi.com
Sphingosine 1-phosphate (S1P) signaling regulates numerous biological processes
including neurogenesis, inflammation and neovascularization. However, little is known …
including neurogenesis, inflammation and neovascularization. However, little is known …
[HTML][HTML] A small natural molecule S3 protects retinal ganglion cells and promotes parkin-mediated mitophagy against excitotoxicity
D Zhuang, R Zhang, H Liu, Y Dai - Molecules, 2022 - mdpi.com
Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in
glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence …
glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence …
Sphingosine 1‐Phosphate Receptor 1 Modulates CNTF‐Induced Axonal Growth and Neuroprotection in the Mouse Visual System
The lack of axonal regeneration and neuronal cell death causes permanent neurological
deficits in the injured CNS. Using the classical CNS injury model of optic nerve crush in …
deficits in the injured CNS. Using the classical CNS injury model of optic nerve crush in …
[HTML][HTML] Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
YJ Gan, Y Cao, ZH Zhang, J Zhang… - Neural Regeneration …, 2023 - journals.lww.com
Abstract Slit-Robo GTPase-activating protein 2 (SRGAP2) plays important roles in axon
guidance, neuronal migration, synapse formation, and nerve regeneration. However, the …
guidance, neuronal migration, synapse formation, and nerve regeneration. However, the …
[HTML][HTML] GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice
S Masuda, S Tanaka, H Shiraki, Y Sotomaru… - Neurobiology of …, 2022 - Elsevier
Glaucoma is an optic neuropathy and is currently one of the most common diseases that
leads to irreversible blindness. The axonal degeneration that occurs before retinal ganglion …
leads to irreversible blindness. The axonal degeneration that occurs before retinal ganglion …
[HTML][HTML] Retinal ganglion cell death is triggered by paraptosis via reactive oxygen species production: a brief literature review presenting a novel hypothesis in …
Y Wang, K Xu, H Zhang, J Zhao… - Molecular …, 2014 - spandidos-publications.com
Accumulative evidence has indicated that apoptosis is the common pathway for retinal
ganglion cell (RGC) death and that autophagy promotes survival of RGCs in glaucoma. In …
ganglion cell (RGC) death and that autophagy promotes survival of RGCs in glaucoma. In …