An environment-dependent transcriptional network specifies human microglia identity
INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …
influence diverse aspects of neuronal function, including refinement of synaptic networks …
A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease
Growing recognition of the pivotal role microglia play in neurodegenerative and
neuroinflammatory disorders has accentuated the need to characterize their function in …
neuroinflammatory disorders has accentuated the need to characterize their function in …
Microglia development follows a stepwise program to regulate brain homeostasis
INTRODUCTION Microglia, as the resident myeloid cells of the central nervous system, play
an important role in life-long brain maintenance and in pathology. Microglia are derived from …
an important role in life-long brain maintenance and in pathology. Microglia are derived from …
Microglia in brain development, homeostasis, and neurodegeneration
CJ Bohlen, BA Friedman, B Dejanovic… - Annual Review of …, 2019 - annualreviews.org
Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …
Transcriptional control of microglia phenotypes in health and disease
IR Holtman, D Skola, CK Glass - The Journal of clinical …, 2017 - Am Soc Clin Investig
Microglia are the main resident macrophage population of the CNS and perform numerous
functions required for CNS development, homeostasis, immunity, and repair. Many lines of …
functions required for CNS development, homeostasis, immunity, and repair. Many lines of …
Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies
KP Lopes, GJL Snijders, J Humphrey, A Allan… - Nature …, 2022 - nature.com
Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function …
how genetic risk for neurological and psychiatric disorders is related to microglial function …
Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
Genome‐wide expression profiling technology has resulted in detailed transcriptome data
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …
Microglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and disease
HA Vecchiarelli, MÈ Tremblay - Annual Review of Genetics, 2023 - annualreviews.org
Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …
derived from the embryonic yolk sac and make their way to the CNS during early …
The transcriptional landscape of microglial genes in aging and neurodegenerative disease
LW Bonham, DW Sirkis, JS Yokoyama - Frontiers in immunology, 2019 - frontiersin.org
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …
A map of transcriptional heterogeneity and regulatory variation in human microglia
AMH Young, N Kumasaka, F Calvert, TR Hammond… - Nature …, 2021 - nature.com
Microglia, the tissue-resident macrophages of the central nervous system (CNS), play critical
roles in immune defense, development and homeostasis. However, isolating microglia from …
roles in immune defense, development and homeostasis. However, isolating microglia from …