An environment-dependent transcriptional network specifies human microglia identity

D Gosselin, D Skola, NG Coufal, IR Holtman… - Science, 2017 - science.org
INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …

A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease

A Patir, B Shih, BW McColl, TC Freeman - Glia, 2019 - Wiley Online Library
Growing recognition of the pivotal role microglia play in neurodegenerative and
neuroinflammatory disorders has accentuated the need to characterize their function in …

Microglia development follows a stepwise program to regulate brain homeostasis

O Matcovitch-Natan, DR Winter, A Giladi… - Science, 2016 - science.org
INTRODUCTION Microglia, as the resident myeloid cells of the central nervous system, play
an important role in life-long brain maintenance and in pathology. Microglia are derived from …

Microglia in brain development, homeostasis, and neurodegeneration

CJ Bohlen, BA Friedman, B Dejanovic… - Annual Review of …, 2019 - annualreviews.org
Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …

Transcriptional control of microglia phenotypes in health and disease

IR Holtman, D Skola, CK Glass - The Journal of clinical …, 2017 - Am Soc Clin Investig
Microglia are the main resident macrophage population of the CNS and perform numerous
functions required for CNS development, homeostasis, immunity, and repair. Many lines of …

Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies

KP Lopes, GJL Snijders, J Humphrey, A Allan… - Nature …, 2022 - nature.com
Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function …

Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

PD Wes, IR Holtman, EWGM Boddeke, T Möller… - Glia, 2016 - Wiley Online Library
Genome‐wide expression profiling technology has resulted in detailed transcriptome data
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …

Microglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and disease

HA Vecchiarelli, MÈ Tremblay - Annual Review of Genetics, 2023 - annualreviews.org
Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …

The transcriptional landscape of microglial genes in aging and neurodegenerative disease

LW Bonham, DW Sirkis, JS Yokoyama - Frontiers in immunology, 2019 - frontiersin.org
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …

A map of transcriptional heterogeneity and regulatory variation in human microglia

AMH Young, N Kumasaka, F Calvert, TR Hammond… - Nature …, 2021 - nature.com
Microglia, the tissue-resident macrophages of the central nervous system (CNS), play critical
roles in immune defense, development and homeostasis. However, isolating microglia from …