Antibody production is an important feature of the vertebrate immune system. Antibodies
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …

Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are
essential for germinal center formation, affinity maturation, and the development of most high …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

The generation of protective antibodies by B cells following natural infection or vaccination
requires 'help'from CD4+ T cells. T follicular helper (Tfh) cells are the specialized CD4+ T …

Background Autoimmune diseases (such as systemic lupus erythematosus, rheumatoid
arthritis, type 1 diabetes, etc) are characterized by the production of autoantibodies against …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

T follicular helper (Tfh) cells are specialized to provide help to B cells and to induce durable
antibody response. Our knowledge on the biology of Tfh cells and their contribution to …

CD4+ T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides
help for germinal center (GC) formation, B-cell development and affinity maturation, and …

T follicular helper (Tfh) cells are a distinct subset of CD4+ T lymphocytes, specialized in B
cell help and in regulation of antibody responses. They are required for the generation of …

The T follicular helper cells (TFH) are a subset of CD4+ T cells specialized to regulate
antibody responses. The production of these cells is associated with the dendritic cells …