Cannabidiol-loaded injectable chitosan-based hydrogels promote spinal cord injury repair by enhancing mitochondrial biogenesis

H Zhang, T Hu, M Xiong, S Li, WX Li, J Liu… - International Journal of …, 2022 - Elsevier
The treatment of traumatic spinal cord injury (SCI) remains challenging as the neuron
regeneration is impaired by irregular cavity and apoptosis. An injectable in situ gelling …

A conductive dual-network hydrogel composed of oxidized dextran and hyaluronic-hydrazide as BDNF delivery systems for potential spinal cord injury repair

F Huang, T Chen, J Chang, C Zhang, F Liao… - International Journal of …, 2021 - Elsevier
Spinal cord injury (SCI) often causes neuronal death and axonal degeneration. In this study,
we report a new strategy for preparing injectable and conductive polysaccharides-based …

An anti-inflammatory peptide and brain-derived neurotrophic factor-modified hyaluronan-methylcellulose hydrogel promotes nerve regeneration in rats with spinal …

Z He, H Zang, L Zhu, K Huang, T Yi… - International Journal …, 2019 - Taylor & Francis
Background Traumatic spinal cord injury (SCI) causes neuronal death, demyelination,
axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in …

Novel thermosensitive hydrogel promotes spinal cord repair by regulating mitochondrial function

Y Li, L Yang, F Hu, J Xu, J Ye, S Liu… - … Applied Materials & …, 2022 - ACS Publications
The repair of spinal cord injury (SCI) is still a tough clinical challenge and needs innovative
therapies. Mitochondrial function is significantly compromised after SCI and has emerged as …

[HTML][HTML] An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury

J Luo, X Shi, L Li, Z Tan, F Feng, J Li, M Pang, X Wang… - Bioactive materials, 2021 - Elsevier
The harsh local micro-environment following spinal cord injury (SCI) remains a great
challenge for neural regeneration. Local reconstitution of a favorable micro-environment by …

Dopamine-modified chitosan hydrogel for spinal cord injury

K Liu, X Dong, Y Wang, X Wu, H Dai - Carbohydrate Polymers, 2022 - Elsevier
Spinal cord injury (SCI) decreases people's both physical and psychological levels. The
rehabilitation of SCI is still a clinical challenging process owing to the inflammatory …

In Situ Cross-Linkable Hyaluronic–Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury

F Sorouri, P Hosseini, M Sharifzadeh… - … Applied Materials & …, 2023 - ACS Publications
Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar
formation, leading to the inhibition of new axon growth and impaired regeneration …

An electroconductive hydrogel scaffold with injectability and biodegradability to manipulate neural stem cells for enhancing spinal cord injury repair

H Liu, Y Feng, S Che, L Guan, X Yang, Y Zhao… - …, 2022 - ACS Publications
Spinal cord injury (SCI) generally leads to long-term functional deficits and is difficult to
repair spontaneously. Many biological scaffold materials and stem cell treatment strategies …

Thermosensitive quaternized chitosan hydrogel scaffolds promote neural differentiation in bone marrow mesenchymal stem cells and functional recovery in a rat …

C Huang, Y Liu, J Ding, Y Dai, L Le, L Wang… - Cell and Tissue …, 2021 - Springer
A thermosensitive quaternary ammonium chloride chitosan/β-glycerophosphate (HACC/β-
GP) hydrogel scaffold combined with bone marrow mesenchymal stem cells (BMSCs) …

Chitosan-based hydrogel to support the paracrine activity of mesenchymal stem cells in spinal cord injury treatment

M Boido, M Ghibaudi, P Gentile, E Favaro, R Fusaro… - Scientific reports, 2019 - nature.com
Advanced therapies which combine cells with biomaterial-based carriers are recognized as
an emerging and powerful method to treat challenging diseases, such as spinal cord injury …