Cytokines of the IL-12 family show structural similarities but have distinct functions in the
immune system. Prominent members of this cytokine family are the pro-inflammatory …

Summary Interleukin-23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-
inflammatory T helper 17 cell responses linked to autoimmune and inflammatory diseases …

The interleukin (IL)-12 family of cytokines, including IL-12 and IL-23, are important mediators
of immune-mediated inflammatory diseases such as psoriasis, multiple sclerosis …

The recent discoveries of the two interleukin (IL)-12-related cytokines, IL-23 and IL-27,
reveal that the regulation of cellular immunity is more complex than originally thought. Until …

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Abstract The cytokines interleukin-12 (IL-12) and IL-23 share a common IL-12/IL-23p40
subunit in structure and play a central role in T cell-mediated responses in inflammation …

The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-
λs (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine …

Cytokines are critical coordinators of the immune response necessary for resolving bacterial
and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key …

T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-
17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells …

Since the discovery of interferons over 50 years ago, efforts to understand the biochemistry,
molecular biology and biological activities of cytokines have been intense and rewarding …