Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Evolutionary dynamics is often viewed as a subtle process of change accumulation that
causes a divergence among organisms and their genomes. However, this interpretation is …

Cancer initiation, progression, and the emergence of therapeutic resistance are evolutionary
phenomena of clonal somatic cell populations. Studies in microbial experimental evolution …

One of the last uncharted territories in evolutionary biology concerns the link with cell
biology. Because all phenotypes ultimately derive from events at the cellular level, this …

Is evolution predictable at the molecular level? The ambitious goal to answer this question
requires an understanding of the mutational effects that govern the complex relationship …

By the time the process of oncogenesis has produced an advanced cancer, tumor cells have
undergone extensive evolution. The cellular phenotypes resulting from this evolution have …

Evolutionary systems biology (ESB) is a rapidly growing integrative approach that has the
core aim of generating mechanistic and evolutionary understanding of genotype‐phenotype …

Fitness landscapes are often described in terms of 'peaks' and 'valleys', indicating an
intuitive low-dimensional landscape of the kind encountered in everyday experience. The …

The problem of complex adaptations is studied in two largely disconnected research
traditions: evolutionary biology and evolutionary computer science. This paper summarizes …

A central unresolved problem of evolutionary biology concerns the way in which evolution at
the genotypic level relates to the evolution of phenotypes. This genotype–phenotype map …