[HTML][HTML] From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
On the networked architecture of genotype spaces and its critical effects on molecular evolution
Evolutionary dynamics is often viewed as a subtle process of change accumulation that
causes a divergence among organisms and their genomes. However, this interpretation is …
causes a divergence among organisms and their genomes. However, this interpretation is …
Cancer in light of experimental evolution
Cancer initiation, progression, and the emergence of therapeutic resistance are evolutionary
phenomena of clonal somatic cell populations. Studies in microbial experimental evolution …
phenomena of clonal somatic cell populations. Studies in microbial experimental evolution …
A theoretical framework for evolutionary cell biology
M Lynch, B Trickovic - Journal of molecular biology, 2020 - Elsevier
One of the last uncharted territories in evolutionary biology concerns the link with cell
biology. Because all phenotypes ultimately derive from events at the cellular level, this …
biology. Because all phenotypes ultimately derive from events at the cellular level, this …
Systems-biology approaches for predicting genomic evolution
Is evolution predictable at the molecular level? The ambitious goal to answer this question
requires an understanding of the mutational effects that govern the complex relationship …
requires an understanding of the mutational effects that govern the complex relationship …
Changing mutational and adaptive landscapes and the genesis of cancer
LA Liggett, J DeGregori - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
By the time the process of oncogenesis has produced an advanced cancer, tumor cells have
undergone extensive evolution. The cellular phenotypes resulting from this evolution have …
undergone extensive evolution. The cellular phenotypes resulting from this evolution have …
Evolutionary systems biology: what it is and why it matters
OS Soyer, MA O'Malley - BioEssays, 2013 - Wiley Online Library
Evolutionary systems biology (ESB) is a rapidly growing integrative approach that has the
core aim of generating mechanistic and evolutionary understanding of genotype‐phenotype …
core aim of generating mechanistic and evolutionary understanding of genotype‐phenotype …
The structure of genotype-phenotype maps makes fitness landscapes navigable
SF Greenbury, AA Louis, SE Ahnert - Nature Ecology & Evolution, 2022 - nature.com
Fitness landscapes are often described in terms of 'peaks' and 'valleys', indicating an
intuitive low-dimensional landscape of the kind encountered in everyday experience. The …
intuitive low-dimensional landscape of the kind encountered in everyday experience. The …
Perspective: complex adaptations and the evolution of evolvability
GP Wagner, L Altenberg - Evolution, 1996 - academic.oup.com
The problem of complex adaptations is studied in two largely disconnected research
traditions: evolutionary biology and evolutionary computer science. This paper summarizes …
traditions: evolutionary biology and evolutionary computer science. This paper summarizes …
The inheritance of process: a dynamical systems approach
A central unresolved problem of evolutionary biology concerns the way in which evolution at
the genotypic level relates to the evolution of phenotypes. This genotype–phenotype map …
the genotypic level relates to the evolution of phenotypes. This genotype–phenotype map …