Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF

S Koch, C Yao, G Grieb, P Prevel, EM Noah… - Journal of Materials …, 2006 - Springer
Since the survival of ingrowing cells in biomaterials for regenerative processes largely
depends on the supply of nutrients and oxygen, angiogenesis plays an important role in the …

Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor

Q He, Y Zhao, B Chen, Z Xiao, J Zhang, L Chen… - Acta biomaterialia, 2011 - Elsevier
Much research has focused on developing vascular endothelial growth factor (VEGF)
delivery systems to enhance angiogenesis in wound repair and in tissue engineering …

The effect of cross-linking of collagen matrices on their angiogenic capability

C Yao, M Markowicz, N Pallua, EM Noah, G Steffens - Biomaterials, 2008 - Elsevier
The poor vascularization rate of matrices following cell invasion is considered to be one of
the main shortcomings of scaffolds used in tissue engineering. In the past decade much …

Modulation of angiogenic potential of collagen matrices by covalent incorporation of heparin and loading with vascular endothelial growth factor

GCM Steffens, C Yao, P Prevel, M Markowicz… - Tissue …, 2004 - liebertpub.com
One of the prominent shortcomings of matrices for tissue engineering is their poor ability to
support angiogenesis. We report here on experiments to enhance the angiogenic properties …

Modification of collagen matrices for enhancing angiogenesis

C Yao, P Prével, S Koch, P Schenck, EM Noah… - Cells Tissues …, 2005 - karger.com
The vascularization of engineered tissues in many cases does not keep up with the ingrowth
of cells. Nutrient and oxygen supply are not sufficient, which ultimately leads to the death of …

Covalently conjugated VEGF–fibrin matrices for endothelialization

AH Zisch, U Schenk, JC Schense… - Journal of Controlled …, 2001 - Elsevier
Vascular endothelial growth factor (VEGF) is a key factor in endothelial cell biology and
blood vessel formation and a candidate therapeutic for the stimulation of angiogenesis …

A biologically active VEGF construct in vitro: Implications for bioengineering‐improved prosthetic vascular grafts

D Stone, M Phaneuf, N Sivamurthy… - … Research: An Official …, 2002 - Wiley Online Library
Prosthetic arterial grafts are unable to develop an intact endothelial lining after implantation,
predisposing them to fail. Strategies have been sought to enhance endothelialization using …

[HTML][HTML] Angiogenic potential of VEGF mimetic peptides for the biofunctionalization of collagen/hydroxyapatite composites

S Wang, F Umrath, W Cen, S Reinert, D Alexander - Biomolecules, 2021 - mdpi.com
Currently, the focus on bioinspired concepts for the development of tissue engineering
constructs is increasing. For this purpose, the combination of collagen (Coll) and …

The impact of proteinase-induced matrix degradation on the release of VEGF from heparinized collagen matrices

C Yao, M Roderfeld, T Rath, E Roeb, J Bernhagen… - Biomaterials, 2006 - Elsevier
The in vivo application of engineered matrices in human wound healing processes is often
hampered by the slow rate of vascularization. Therefore much research is directed towards …

Enhanced angiogenesis of porous collagen scaffolds by incorporation of TMC/DNA complexes encoding vascular endothelial growth factor

Z Mao, H Shi, R Guo, L Ma, C Gao, C Han, J Shen - Acta Biomaterialia, 2009 - Elsevier
Angiogenesis of an implanted construct is one of the most important issues in tissue
engineering and regenerative medicine, and can often take as long as several weeks. The …