The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as
xCT) plays a key role in antioxidant defense by mediating cystine uptake, promoting …

Amino acid transporters mediate substrates across cellular membranes and their fine-tuned
regulations are critical to cellular metabolism, growth, and death. As the functional …

The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …

The solute carrier family 7 member 11 (SLC7A11), an amino acid transporter protein is
frequently overexpressed in human malignancies. The expression and activity of SLC7A11 …

Cancer cells with specific genetic alterations may be highly dependent on certain nutrients
for survival, which can inform therapeutic strategies to target these cancer-specific metabolic …

System xc− cystine/glutamate antiporter, composed of a light-chain subunit (xCT, SLC7A11)
and a heavy-chain subunit (CD98hc, SLC3A2), is mainly responsible for the cellular uptake …

SLC7A11 is a cell transmembrane protein composing the light chain of system xc−,
transporting extracellular cystine into cells for cysteine production and GSH biosynthesis …