The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Direct functionalization of C single bondH bond is rapidly becoming an indispensible tool in
chemical synthesis. However, due to the ubiquity of Csingle bond H bonds, achieving site …

High selectivity and exquisite control over the outcome of reactions entice chemists to use
biocatalysts in organic synthesis. However, many useful reactions are not accessible …

Recent developments to modify enzymes for use in organic synthesis have targeted several
areas. These include altering the reaction mechanism of the enzyme to catalyse new …

Although nature evolves its catalysts over millions of years, enzyme engineers try to do it a
bit faster. Enzyme active sites provide highly optimized microenvironments for the catalysis …

Biocatalysis has expanded rapidly in the last decades with the discoveries of highly
stereoselective enzymes with broad substrate specificity. A new frontier for biocatalysis is …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

New chemo-and biocatalytic methodology is important for the future sustainable synthesis of
essential molecules. Transition metal catalysis enables the late-stage C− H functionalization …

Enzymes are able to perform a multitude of chemical and biochemical transformations with
efficiencies that are typically unrivalled by chemical catalysts. However, these evolved …