Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression

RC Shelton, AH Miller - Progress in neurobiology, 2010 - Elsevier
Obesity and related metabolic conditions are of epidemic proportions in most of the world,
affecting both adults and children. The accumulation of lipids in the body in the form of white …

Inflammation in depression: is adiposity a cause?

R C. Shelton, A H. Miller - Dialogues in clinical neuroscience, 2011 - Taylor & Francis
Mounting evidence indicates that inflammation may play a significant role in the
development of depression. Patients with depression exhibit increased inflammatory …

[HTML][HTML] Role of adiposity-driven inflammation in depressive morbidity

L Capuron, J Lasselin, N Castanon - Neuropsychopharmacology, 2017 - nature.com
Depression and metabolic disorders, including overweight and obesity, appear tightly
interrelated. The prevalence of these conditions is concurrently growing worldwide, and both …

Pathways linking depression, adiposity, and inflammatory markers in healthy young adults

GE Miller, KE Freedland, RM Carney, CA Stetler… - Brain, behavior, and …, 2003 - Elsevier
Despite mounting evidence that depression increases risk for cardiovascular morbidity and
mortality, little is known about the mechanisms responsible for this association. The current …

[HTML][HTML] Metabolic disturbances connecting obesity and depression

C Hryhorczuk, S Sharma, SE Fulton - Frontiers in neuroscience, 2013 - frontiersin.org
Obesity markedly increases the odds of developing depression. Depressed mood not only
impairs motivation, quality of life and overall functioning but also increases the risks of …

[HTML][HTML] The menace of obesity to depression and anxiety prevalence

S Fulton, L Décarie-Spain, X Fioramonti… - Trends in Endocrinology …, 2022 - cell.com
The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

[HTML][HTML] Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

X Fu, Y Wang, F Zhao, R Cui, W Xie, Q Liu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Depression and obesity are both common disorders currently affecting public health,
frequently occurring simultaneously within individuals, and the relationship between these …

[HTML][HTML] Inflammatory depression—mechanisms and non-pharmacological interventions

K Suneson, J Lindahl, S Chamli Hårsmar… - International journal of …, 2021 - mdpi.com
Treatment of depression is hampered by the failure to identify distinct symptom profiles with
distinct pathophysiologies that differentially respond to distinct treatments. We posit that …

Inflammatory cytokine-associated depression

FE Lotrich - Brain research, 2015 - Elsevier
Inflammatory cytokines can sometimes trigger depression in humans, are often associated
with depression, and can elicit some behaviors in animals that are homologous to major …

Central and peripheral inflammation link metabolic syndrome and major depressive disorder

KL Chan, F Cathomas, SJ Russo - Physiology, 2019 - journals.physiology.org
Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …